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2o5v

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{{Structure
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The line below this paragraph, containing "STRUCTURE_2o5v", creates the "Structure Box" on the page.
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|GENE= recF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 Deinococcus radiodurans])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o5v OCA], [http://www.ebi.ac.uk/pdbsum/2o5v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o5v RCSB]</span>
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'''Recombination mediator RecF'''
'''Recombination mediator RecF'''
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[[Category: Korolev, S.]]
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[[Category: p-loop]]
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[[Category: signature motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:22:00 2008''
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Revision as of 07:22, 4 May 2008

Image:2o5v.gif

Template:STRUCTURE 2o5v

Recombination mediator RecF


Overview

RecF, together with RecO and RecR, belongs to a ubiquitous group of recombination mediators (RMs) that includes eukaryotic proteins such as Rad52 and BRCA2. RMs help maintain genome stability in the presence of DNA damage by loading RecA-like recombinases and displacing single-stranded DNA-binding proteins. Here, we present the crystal structure of RecF from Deinococcus radiodurans. RecF exhibits a high degree of structural similarity with the head domain of Rad50, but lacks its long coiled-coil region. The structural homology between RecF and Rad50 is extensive, encompassing the ATPase subdomain and the so-called 'Lobe II' subdomain of Rad50. The pronounced structural conservation between bacterial RecF and evolutionarily diverged eukaryotic Rad50 implies a conserved mechanism of DNA binding and recognition of the boundaries of double-stranded DNA regions. The RecF structure, mutagenesis of conserved motifs and ATP-dependent dimerization of RecF are discussed with respect to its role in promoting presynaptic complex formation at DNA damage sites.

About this Structure

2O5V is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structural conservation of RecF and Rad50: implications for DNA recognition and RecF function., Koroleva O, Makharashvili N, Courcelle CT, Courcelle J, Korolev S, EMBO J. 2007 Feb 7;26(3):867-77. Epub 2007 Jan 25. PMID:17255941 Page seeded by OCA on Sun May 4 10:22:00 2008

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