2oc8

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[[Image:2oc8.jpg|left|200px]]
[[Image:2oc8.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2oc8 |SIZE=350|CAPTION= <scene name='initialview01'>2oc8</scene>, resolution 2.66&Aring;
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The line below this paragraph, containing "STRUCTURE_2oc8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=HU5:(1R,2S,5S)-N-[(1S)-3-AMINO-1-(CYCLOBUTYLMETHYL)-2,3-DIOXOPROPYL]-3-[(2S)-2-{[(TERT-BUTYLAMINO)CARBONYL]AMINO}-3,3-DIMETHYLBUTANOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE'>HU5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
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-->
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|DOMAIN=
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{{STRUCTURE_2oc8| PDB=2oc8 | SCENE= }}
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|RELATEDENTRY=[[2obo|2OBO]], [[2oc1|2OC1]], [[2oc0|2OC0]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oc8 OCA], [http://www.ebi.ac.uk/pdbsum/2oc8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oc8 RCSB]</span>
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}}
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'''Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034'''
'''Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034'''
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[[Category: Yarosh-Tomaine, T.]]
[[Category: Yarosh-Tomaine, T.]]
[[Category: Zhang, R.]]
[[Category: Zhang, R.]]
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[[Category: hcv]]
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[[Category: Hcv]]
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[[Category: hepatitis c virus]]
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[[Category: Hepatitis c virus]]
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[[Category: ketoamide inhibitor]]
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[[Category: Ketoamide inhibitor]]
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[[Category: ns3 protease domain]]
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[[Category: Ns3 protease domain]]
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[[Category: viral protein]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:35:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:15:45 2008''
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Revision as of 07:35, 4 May 2008

Image:2oc8.jpg

Template:STRUCTURE 2oc8

Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034


Overview

An estimated 1% of the global human population is infected by hepatitis C viruses (HCVs), and there are no broadly effective treatments for the debilitating progression of chronic hepatitis C. A serine protease located within the HCV NS3 protein processes the viral polyprotein at four specific sites and is considered essential for replication. Thus, it emerges as an attractive target for drug design. We report here the 2.5 angstrom resolution X-ray crystal structure of the NS3 protease domain complexed with a synthetic NS4A activator peptide. The protease has a chymotrypsin-like fold and features a tetrahedrally coordinated metal ion distal to the active site. The NS4A peptide intercalates within a beta sheet of the enzyme core.

About this Structure

2OC8 is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:8861917 Page seeded by OCA on Sun May 4 10:35:35 2008

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OCA

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