2of4

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[[Image:2of4.gif|left|200px]]
[[Image:2of4.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2of4 |SIZE=350|CAPTION= <scene name='initialview01'>2of4</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_2of4", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=979:5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE'>979</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= LCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2of4| PDB=2of4 | SCENE= }}
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|RELATEDENTRY=[[2of2|2OF2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2of4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2of4 OCA], [http://www.ebi.ac.uk/pdbsum/2of4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2of4 RCSB]</span>
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}}
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'''crystal structure of furanopyrimidine 1 bound to lck'''
'''crystal structure of furanopyrimidine 1 bound to lck'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Martin, M W.]]
[[Category: Martin, M W.]]
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[[Category: kinase domain]]
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[[Category: Kinase domain]]
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[[Category: lck]]
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[[Category: Lck]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:46:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:16:52 2008''
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Revision as of 07:46, 4 May 2008

Image:2of4.gif

Template:STRUCTURE 2of4

crystal structure of furanopyrimidine 1 bound to lck


Contents

Overview

2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties.

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

2OF4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties., Martin MW, Newcomb J, Nunes JJ, Bemis JE, McGowan DC, White RD, Buchanan JL, DiMauro EF, Boucher C, Faust T, Hsieh F, Huang X, Lee JH, Schneider S, Turci SM, Zhu X, Bioorg Med Chem Lett. 2007 Apr 15;17(8):2299-304. Epub 2007 Jan 24. PMID:17276681 Page seeded by OCA on Sun May 4 10:46:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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