2oit
From Proteopedia
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[[Image:2oit.gif|left|200px]] | [[Image:2oit.gif|left|200px]] | ||
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'''Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN''' | '''Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN''' | ||
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[[Category: Hoelz, A.]] | [[Category: Hoelz, A.]] | ||
[[Category: Napetschnig, J.]] | [[Category: Napetschnig, J.]] | ||
| - | [[Category: | + | [[Category: Beta-propeller]] |
| - | [[Category: | + | [[Category: Dbp5/ddx19]] |
| - | [[Category: | + | [[Category: Leukemia]] |
| - | [[Category: | + | [[Category: Mrna export]] |
| - | [[Category: | + | [[Category: Nh2 terminal domain of nup214/can]] |
| - | [[Category: | + | [[Category: Npc assembly]] |
| - | [[Category: | + | [[Category: Nup214/can fusion]] |
| - | [[Category: | + | [[Category: Structure]] |
| - | [[Category: | + | [[Category: X-ray crystallography]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:00:13 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:00, 4 May 2008
Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN
Contents |
Overview
The mammalian nuclear pore complex (NPC) is an approximately 120-MDa proteinaceous assembly consisting of approximately 30 proteins and is the sole gate in the nuclear envelope. The human protooncogene Nup214 was first identified as a target for chromosomal translocation involved in leukemogenesis. Nup214 is located on the cytoplasmic face of the NPC and is implicated in anchoring the cytoplasmic filaments of the NPC and recruiting the RNA helicase Ddx19. Here, we present the crystal structure of the human Nup214 N-terminal domain at 1.65-A resolution. The structure reveals a seven-bladed beta-propeller followed by a 30-residue C-terminal extended peptide segment, which folds back onto the beta-propeller and binds to its bottom face. The beta-propeller repeats lack any recognizable sequence motif and are distinguished by extensive insertions between the canonical beta-strands. We propose a mechanism by which the C-terminal peptide extension is involved in NPC assembly.
Disease
Known disease associated with this structure: Leukemia, T-cell acute lymphoblastic OMIM:[114350], Leukemia, acute myeloid OMIM:[114350]
About this Structure
2OIT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN., Napetschnig J, Blobel G, Hoelz A, Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1783-8. Epub 2007 Jan 30. PMID:17264208 Page seeded by OCA on Sun May 4 11:00:13 2008
