2ojq

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[[Image:2ojq.gif|left|200px]]
[[Image:2ojq.gif|left|200px]]
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{{Structure
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|PDB= 2ojq |SIZE=350|CAPTION= <scene name='initialview01'>2ojq</scene>, resolution 2.87&Aring;
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The line below this paragraph, containing "STRUCTURE_2ojq", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|GENE= PDCD6IP, AIP1, ALIX, KIAA1375 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2ojq| PDB=2ojq | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ojq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ojq OCA], [http://www.ebi.ac.uk/pdbsum/2ojq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ojq RCSB]</span>
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'''Crystal structure of Alix V domain'''
'''Crystal structure of Alix V domain'''
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[[Category: Hurley, J H.]]
[[Category: Hurley, J H.]]
[[Category: Lee, S.]]
[[Category: Lee, S.]]
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[[Category: helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:03:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:18:48 2008''
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Revision as of 08:03, 4 May 2008

Image:2ojq.gif

Template:STRUCTURE 2ojq

Crystal structure of Alix V domain


Overview

The modular protein Alix is a central node in endosomal-lysosomal trafficking and the budding of human immunodeficiency virus (HIV)-1. The Gag p6 protein of HIV-1 contains a LYPx(n)LxxL motif that is required for Alix-mediated budding and binds a region of Alix spanning residues 360-702. The structure of this fragment of Alix has the shape of the letter 'V' and is termed the V domain. The V domain has a topologically complex arrangement of 11 alpha-helices, with connecting loops that cross three times between the two arms of the V. The conserved residue Phe676 is at the center of a large hydrophobic pocket and is crucial for binding to a peptide model of HIV-1 p6. Overexpression of the V domain inhibits HIV-1 release from cells. This inhibition of release is reversed by mutations that block binding of the Alix V domain to p6.

About this Structure

2OJQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for viral late-domain binding to Alix., Lee S, Joshi A, Nagashima K, Freed EO, Hurley JH, Nat Struct Mol Biol. 2007 Mar;14(3):194-9. Epub 2007 Feb 4. PMID:17277784 Page seeded by OCA on Sun May 4 11:03:27 2008

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