2ok5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2ok5.jpg|left|200px]]
[[Image:2ok5.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2ok5 |SIZE=350|CAPTION= <scene name='initialview01'>2ok5</scene>, resolution 2.30&Aring;
+
The line below this paragraph, containing "STRUCTURE_2ok5", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase Alternative-complement-pathway C3/C5 convertase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= CFB, BF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2ok5| PDB=2ok5 | SCENE= }}
-
|RELATEDENTRY=[[2i6q|2I6Q]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ok5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ok5 OCA], [http://www.ebi.ac.uk/pdbsum/2ok5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ok5 RCSB]</span>
+
-
}}
+
'''Human Complement factor B'''
'''Human Complement factor B'''
Line 36: Line 33:
[[Category: Roos, A.]]
[[Category: Roos, A.]]
[[Category: Schouten, A.]]
[[Category: Schouten, A.]]
-
[[Category: ccp domain]]
+
[[Category: Ccp domain]]
-
[[Category: pro-enzyme]]
+
[[Category: Pro-enzyme]]
-
[[Category: serine protease domain,von willebrand factor-a domain]]
+
[[Category: Serine protease domain,von willebrand factor-a domain]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:04:38 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:19:01 2008''
+

Revision as of 08:04, 4 May 2008

Image:2ok5.jpg

Template:STRUCTURE 2ok5

Human Complement factor B


Overview

Factor B is the central protease of the complement system of immune defense. Here, we present the crystal structure of human factor B at 2.3-A resolution, which reveals how the five-domain proenzyme is kept securely inactive. The canonical activation helix of the Von Willebrand factor A (VWA) domain is displaced by a helix from the preceding domain linker. The two helices conformationally link the scissile-activation peptide and the metal ion-dependent adhesion site required for binding of the ligand C3b. The data suggest that C3b binding displaces the three N-terminal control domains and reshuffles the two central helices. Reshuffling of the helices releases the scissile bond for final proteolytic activation and generates a new interface between the VWA domain and the serine protease domain. This allosteric mechanism is crucial for tight regulation of the complement-amplification step in the immune response.

About this Structure

2OK5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Factor B structure provides insights into activation of the central protease of the complement system., Milder FJ, Gomes L, Schouten A, Janssen BJ, Huizinga EG, Romijn RA, Hemrika W, Roos A, Daha MR, Gros P, Nat Struct Mol Biol. 2007 Mar;14(3):224-8. Epub 2007 Feb 25. PMID:17310251 Page seeded by OCA on Sun May 4 11:04:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ok5"
Personal tools