2okl
From Proteopedia
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'''Crystal structure of Peptide Deformylase 2 with actinonin from Bacillus cereus''' | '''Crystal structure of Peptide Deformylase 2 with actinonin from Bacillus cereus''' | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kim, E E.]] | [[Category: Kim, E E.]] | ||
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Revision as of 08:06, 4 May 2008
Crystal structure of Peptide Deformylase 2 with actinonin from Bacillus cereus
Overview
Peptide deformylase (PDF) is a metalloenzyme that removes the N-terminal formyl groups from newly synthesized proteins. It is essential for bacterial survival, and is therefore-considered as a potential target for antimicrobial chemotherapy. However, some bacteria including medically relevant pathogens possess two or more def-like genes. Here we have examined two PDFs from Bacillus cereus. The two share only 32% sequence identity and the crystal structures show overall similarity with PDF2 having a longer C-terminus. However, there are differences at the two active sites, and these differences appear to contribute to the activity difference seen between the two. BcPDF2 is found as a dimer in the crystal form with two additional actinonin bound at that interface.
About this Structure
2OKL is a Single protein structure of sequence from Bacillus cereus. Full crystallographic information is available from OCA.
Reference
Characterization of peptide deformylase2 from B. cereus., Park JK, Kim KH, Moon JH, Kim EE, J Biochem Mol Biol. 2007 Nov 30;40(6):1050-7. PMID:18047803 Page seeded by OCA on Sun May 4 11:06:27 2008