2okl

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[[Image:2okl.jpg|left|200px]]
[[Image:2okl.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2okl |SIZE=350|CAPTION= <scene name='initialview01'>2okl</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_2okl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= def2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 Bacillus cereus])
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-->
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|DOMAIN=
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{{STRUCTURE_2okl| PDB=2okl | SCENE= }}
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|RELATEDENTRY=[[1ws0|1WS0]], [[1ws1|1WS1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2okl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okl OCA], [http://www.ebi.ac.uk/pdbsum/2okl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2okl RCSB]</span>
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}}
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'''Crystal structure of Peptide Deformylase 2 with actinonin from Bacillus cereus'''
'''Crystal structure of Peptide Deformylase 2 with actinonin from Bacillus cereus'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Kim, E E.]]
[[Category: Kim, E E.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:06:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:19:11 2008''
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Revision as of 08:06, 4 May 2008

Template:STRUCTURE 2okl

Crystal structure of Peptide Deformylase 2 with actinonin from Bacillus cereus


Overview

Peptide deformylase (PDF) is a metalloenzyme that removes the N-terminal formyl groups from newly synthesized proteins. It is essential for bacterial survival, and is therefore-considered as a potential target for antimicrobial chemotherapy. However, some bacteria including medically relevant pathogens possess two or more def-like genes. Here we have examined two PDFs from Bacillus cereus. The two share only 32% sequence identity and the crystal structures show overall similarity with PDF2 having a longer C-terminus. However, there are differences at the two active sites, and these differences appear to contribute to the activity difference seen between the two. BcPDF2 is found as a dimer in the crystal form with two additional actinonin bound at that interface.

About this Structure

2OKL is a Single protein structure of sequence from Bacillus cereus. Full crystallographic information is available from OCA.

Reference

Characterization of peptide deformylase2 from B. cereus., Park JK, Kim KH, Moon JH, Kim EE, J Biochem Mol Biol. 2007 Nov 30;40(6):1050-7. PMID:18047803 Page seeded by OCA on Sun May 4 11:06:27 2008

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