2okr

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[[Image:2okr.gif|left|200px]]
[[Image:2okr.gif|left|200px]]
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{{Structure
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|PDB= 2okr |SIZE=350|CAPTION= <scene name='initialview01'>2okr</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_2okr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= MAPK14, CSBP, CSBP1, CSBP2, MXI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2okr| PDB=2okr | SCENE= }}
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|RELATEDENTRY=[[2onl|2ONL]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2okr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okr OCA], [http://www.ebi.ac.uk/pdbsum/2okr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2okr RCSB]</span>
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'''Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer'''
'''Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Haar, E Ter.]]
[[Category: Haar, E Ter.]]
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[[Category: docking groove]]
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[[Category: Docking groove]]
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[[Category: heterodimer]]
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[[Category: Heterodimer]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: ne]]
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[[Category: Ne]]
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[[Category: nl]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:06:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:19:17 2008''
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Revision as of 08:06, 4 May 2008

Image:2okr.gif

Template:STRUCTURE 2okr

Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer


Overview

The p38 signaling pathway is activated in response to cell stress and induces production of proinflammatory cytokines. P38alpha is phosphorylated and activated in response to cell stress by MKK3 and MKK6 and in turn phosphorylates a number of substrates, including MAPKAP kinase 2 (MK2). We have determined the crystal structure of the unphosphorylated p38alpha-MK2 heterodimer. The C-terminal regulatory domain of MK2 binds in the docking groove of p38alpha, and the ATP-binding sites of both kinases are at the heterodimer interface. The conformation suggests an extra mechanism in addition to the regulation of the p38alpha and MK2 phosphorylation states that prevents phosphorylation of substrates in the absence of cell stress. Addition of constitutively active MKK6-DD results in rapid phosphorylation of the p38alpha-MK2 heterodimer.

About this Structure

2OKR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer., ter Haar E, Prabhakar P, Liu X, Lepre C, J Biol Chem. 2007 Mar 30;282(13):9733-9. Epub 2007 Jan 25. PMID:17255097 Page seeded by OCA on Sun May 4 11:06:52 2008

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