2ong
From Proteopedia
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[[Image:2ong.gif|left|200px]] | [[Image:2ong.gif|left|200px]] | ||
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'''Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).''' | '''Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).''' | ||
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[[Category: 2 fluorogeranyl diphosphate]] | [[Category: 2 fluorogeranyl diphosphate]] | ||
[[Category: 2-fluorolinalyl diphosphate]] | [[Category: 2-fluorolinalyl diphosphate]] | ||
| - | [[Category: | + | [[Category: Crystal structure]] |
| - | [[Category: | + | [[Category: Geranyl diphosphate]] |
| - | [[Category: | + | [[Category: Linalyl diphosphate]] |
| - | [[Category: | + | [[Category: Monoterpene cyclase]] |
| - | [[Category: | + | [[Category: Monoterpene synthase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:15:51 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:15, 4 May 2008
Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).
Overview
The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction.
About this Structure
2ONG is a Single protein structure of sequence from Mentha spicata. Full crystallographic information is available from OCA.
Reference
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193 Page seeded by OCA on Sun May 4 11:15:51 2008
