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2onh

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[[Image:2onh.gif|left|200px]]
[[Image:2onh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2onh |SIZE=350|CAPTION= <scene name='initialview01'>2onh</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_2onh", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+A+601'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+602'>AC2</scene>, <scene name='pdbsite=AC3:Mn+Binding+Site+For+Residue+A+603'>AC3</scene>, <scene name='pdbsite=AC4:Mn+Binding+Site+For+Residue+B+1601'>AC4</scene>, <scene name='pdbsite=AC5:Mn+Binding+Site+For+Residue+B+1602'>AC5</scene>, <scene name='pdbsite=AC6:Mn+Binding+Site+For+Residue+B+1603'>AC6</scene>, <scene name='pdbsite=AC7:F3p+Binding+Site+For+Residue+A+600'>AC7</scene>, <scene name='pdbsite=AC8:Btb+Binding+Site+For+Residue+A+604'>AC8</scene> and <scene name='pdbsite=AC9:F3p+Binding+Site+For+Residue+B+1600'>AC9</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=F3P:(1S)-1-[(1S)-1-FLUOROETHYL]-1,5-DIMETHYLHEXYL+TRIHYDROGEN+DIPHOSPHATE'>F3P</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2onh| PDB=2onh | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onh OCA], [http://www.ebi.ac.uk/pdbsum/2onh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2onh RCSB]</span>
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}}
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'''Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)'''
'''Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)'''
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[[Category: 2 fluorogeranyl diphosphate]]
[[Category: 2 fluorogeranyl diphosphate]]
[[Category: 2-fluorolinalyl diphosphate]]
[[Category: 2-fluorolinalyl diphosphate]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: geranyl diphosphate]]
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[[Category: Geranyl diphosphate]]
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[[Category: linalyl diphosphate]]
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[[Category: Linalyl diphosphate]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: monoterpene cyclase]]
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[[Category: Monoterpene cyclase]]
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[[Category: monoterpene synthase]]
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[[Category: Monoterpene synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:15:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:20:19 2008''
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Revision as of 08:16, 4 May 2008

Image:2onh.gif

Template:STRUCTURE 2onh

Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)


Overview

The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction.

About this Structure

2ONH is a Single protein structure of sequence from Mentha spicata. Full crystallographic information is available from OCA.

Reference

Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193 Page seeded by OCA on Sun May 4 11:15:59 2008

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