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2onj
From Proteopedia
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[[Image:2onj.gif|left|200px]] | [[Image:2onj.gif|left|200px]] | ||
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'''Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP''' | '''Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP''' | ||
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[[Category: Dawson, R J.P.]] | [[Category: Dawson, R J.P.]] | ||
[[Category: Locher, K P.]] | [[Category: Locher, K P.]] | ||
| - | [[Category: | + | [[Category: Integral membrane protein]] |
| - | [[Category: | + | [[Category: Transport protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:16:21 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:16, 4 May 2008
Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP
Overview
Staphylococcus aureus Sav1866 is a bacterial homolog of the human ABC transporter Mdr1 that causes multidrug resistance in cancer cells. We report the crystal structure of Sav1866 in complex with adenosine-5'-(beta,gamma-imido)triphosphate (AMP-PNP) at 3.4A resolution and compare it with the previously determined structure of Sav1866 with bound ADP. Besides differences in the ATP-binding sites, no significant conformational changes were observed. The results confirm that the ATP-bound state of multidrug ABC transporters is coupled to an outward-facing conformation of the transmembrane domains.
About this Structure
2ONJ is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP., Dawson RJ, Locher KP, FEBS Lett. 2007 Mar 6;581(5):935-8. Epub 2007 Feb 7. PMID:17303126 Page seeded by OCA on Sun May 4 11:16:21 2008
