2oo4

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[[Image:2oo4.gif|left|200px]]
[[Image:2oo4.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2oo4 |SIZE=350|CAPTION= <scene name='initialview01'>2oo4</scene>, resolution 2.003&Aring;
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The line below this paragraph, containing "STRUCTURE_2oo4", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NOTCH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2oo4| PDB=2oo4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oo4 OCA], [http://www.ebi.ac.uk/pdbsum/2oo4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oo4 RCSB]</span>
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}}
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'''Structure of LNR-HD (Negative Regulatory Region) from human Notch 2'''
'''Structure of LNR-HD (Negative Regulatory Region) from human Notch 2'''
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[[Category: Sanchez-Irizarry, C.]]
[[Category: Sanchez-Irizarry, C.]]
[[Category: Vardar-Ulu, D.]]
[[Category: Vardar-Ulu, D.]]
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[[Category: alpha-beta-sandwich]]
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[[Category: Alpha-beta-sandwich]]
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[[Category: cysteine-rich]]
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[[Category: Cysteine-rich]]
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[[Category: hd domain]]
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[[Category: Hd domain]]
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[[Category: lin12 notch repeat]]
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[[Category: Lin12 notch repeat]]
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[[Category: lnr]]
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[[Category: Lnr]]
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[[Category: sea domain]]
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[[Category: Sea domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:18:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:20:38 2008''
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Revision as of 08:18, 4 May 2008

Image:2oo4.gif

Template:STRUCTURE 2oo4

Structure of LNR-HD (Negative Regulatory Region) from human Notch 2


Contents

Overview

Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing that a substantial conformational movement is necessary to expose this site during activation by ligand. Leukemia-associated mutations in NOTCH1 probably release autoinhibition by destabilizing the conserved hydrophobic core of the NRR.

Disease

Known disease associated with this structure: Alagille syndrome 2 OMIM:[600275]

About this Structure

2OO4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for autoinhibition of Notch., Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC, Nat Struct Mol Biol. 2007 Apr;14(4):295-300. Epub 2007 Apr 1. PMID:17401372 Page seeded by OCA on Sun May 4 11:18:20 2008

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OCA

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