2oot

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[[Image:2oot.gif|left|200px]]
[[Image:2oot.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2oot |SIZE=350|CAPTION= <scene name='initialview01'>2oot</scene>, resolution 1.64&Aring;
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The line below this paragraph, containing "STRUCTURE_2oot", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II Glutamate carboxypeptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.21 3.4.17.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FOLH1, FOLH, NAALAD1, PSM, PSMA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2oot| PDB=2oot | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oot OCA], [http://www.ebi.ac.uk/pdbsum/2oot PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oot RCSB]</span>
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}}
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'''A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II'''
'''A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II'''
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[[Category: Barinka, C.]]
[[Category: Barinka, C.]]
[[Category: Lubkowski, J.]]
[[Category: Lubkowski, J.]]
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[[Category: folate hydrolase]]
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[[Category: Folate hydrolase]]
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[[Category: gcpii]]
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[[Category: Gcpii]]
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[[Category: metallopeptidase]]
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[[Category: Metallopeptidase]]
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[[Category: naaladase]]
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[[Category: Naaladase]]
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[[Category: prostate-specific membrane antigen]]
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[[Category: Prostate-specific membrane antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:21:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:20:55 2008''
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Revision as of 08:21, 4 May 2008

Image:2oot.gif

Template:STRUCTURE 2oot

A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II


Overview

Human glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) is an established marker for prostate-cancer diagnosis as well as a candidate therapeutic target for the treatment of diverse pathologies that involve glutamatergic transmission. Structural data on GCPII are thus valuable for the design and optimization of GCPII-specific inhibitors and diagnostic probes. The currently available structure of ligand-free GCPII was refined to a resolution of 3.5 A. This work reports the structure of the protein refined to 1.65 A resolution, with crystallographic values of R = 0.207 and R(free) = 0.228. The new structure extends the resolution appreciably and the new model based on this data shows significant differences when compared with the previously published model.

About this Structure

2OOT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A high-resolution structure of ligand-free human glutamate carboxypeptidase II., Barinka C, Starkova J, Konvalinka J, Lubkowski J, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt, 3):150-3. Epub 2007 Feb 13. PMID:17329803 Page seeded by OCA on Sun May 4 11:21:00 2008

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OCA

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