2opy

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[[Image:2opy.gif|left|200px]]
[[Image:2opy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2opy |SIZE=350|CAPTION= <scene name='initialview01'>2opy</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_2opy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CO9:1-({2-[(1S)-1-AMINOETHYL]-1,3-OXAZOL-4-YL}CARBONYL)-L-PROLYL-L-TRYPTOPHAN'>CO9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= BIRC4, API3, IAP3, XIAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2opy| PDB=2opy | SCENE= }}
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|RELATEDENTRY=[[1g3f|1G3F]], [[1g73|1G73]], [[2i3h|2I3H]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opy OCA], [http://www.ebi.ac.uk/pdbsum/2opy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2opy RCSB]</span>
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}}
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'''Smac mimic bound to BIR3-XIAP'''
'''Smac mimic bound to BIR3-XIAP'''
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[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
[[Category: Wist, A D.]]
[[Category: Wist, A D.]]
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[[Category: bir3]]
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[[Category: Bir3]]
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[[Category: peptide mimic]]
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[[Category: Peptide mimic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:25:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:21:30 2008''
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Revision as of 08:25, 4 May 2008

Image:2opy.gif

Template:STRUCTURE 2opy

Smac mimic bound to BIR3-XIAP


Overview

A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP.

About this Structure

2OPY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP., Wist AD, Gu L, Riedl SJ, Shi Y, McLendon GL, Bioorg Med Chem. 2007 Apr 15;15(8):2935-43. Epub 2007 Feb 11. PMID:17336535 Page seeded by OCA on Sun May 4 11:25:02 2008

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OCA

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