2osz
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2osz.gif|left|200px]] | [[Image:2osz.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2osz", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_2osz| PDB=2osz | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding''' | '''Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding''' | ||
| Line 28: | Line 25: | ||
[[Category: Hoelz, A.]] | [[Category: Hoelz, A.]] | ||
[[Category: Melcak, I.]] | [[Category: Melcak, I.]] | ||
| - | [[Category: | + | [[Category: Npc]] |
| - | [[Category: | + | [[Category: Nucleoporin]] |
| - | [[Category: | + | [[Category: Structure]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:35:53 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:35, 4 May 2008
Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding
Overview
The nucleoporins Nup58 and Nup45 are part of the central transport channel of the nuclear pore complex, which is thought to have a flexible diameter. In the crystal structure of an alpha-helical region of mammalian Nup58/45, we identified distinct tetramers, each consisting of two antiparallel hairpin dimers. The intradimeric interface is hydrophobic, whereas dimer-dimer association occurs through large hydrophilic residues. These residues are laterally displaced in various tetramer conformations, which suggests an intermolecular sliding by 11 angstroms. We propose that circumferential sliding plays a role in adjusting the diameter of the central transport channel.
About this Structure
2OSZ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding., Melcak I, Hoelz A, Blobel G, Science. 2007 Mar 23;315(5819):1729-32. PMID:17379812 Page seeded by OCA on Sun May 4 11:35:53 2008
