2ot2

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[[Image:2ot2.jpg|left|200px]]
[[Image:2ot2.jpg|left|200px]]
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{{Structure
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|PDB= 2ot2 |SIZE=350|CAPTION= <scene name='initialview01'>2ot2</scene>
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The line below this paragraph, containing "STRUCTURE_2ot2", creates the "Structure Box" on the page.
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|GENE= hypC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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{{STRUCTURE_2ot2| PDB=2ot2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ot2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ot2 OCA], [http://www.ebi.ac.uk/pdbsum/2ot2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ot2 RCSB]</span>
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'''Solution Structure of HypC'''
'''Solution Structure of HypC'''
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[[Category: Jin, C.]]
[[Category: Jin, C.]]
[[Category: Wang, L.]]
[[Category: Wang, L.]]
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[[Category: beta barrel]]
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[[Category: Beta barrel]]
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[[Category: chaperone]]
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[[Category: Chaperone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:36:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:22:45 2008''
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Revision as of 08:36, 4 May 2008

Template:STRUCTURE 2ot2

Solution Structure of HypC


Overview

Escherichia coli HypC plays an important role in the maturation process of the pre-maturated HycE, the large subunit of hydrogenase 3. It serves as an iron transfer as well as a chaperone protein during the maturation process of pre-HycE, and interacts with both HypD and HycE. The N-terminal cysteine residue of HypC plays a key role in the protein-protein interactions. Here, we present the three-dimensional structure of E. coli HypC, the first solution structure of HupF/HypC family. Our result demonstrates that E. coli HypC consists of a typical OB-fold beta-barrel with two C-terminal helixes. Sequence alignment and structural comparison reveal that the hydrophobic region on the surface of E. coli HypC, as well as the highly flexible C-terminal helixes, may involve in the interactions of E. coli HypC with other proteins.

About this Structure

2OT2 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Solution structure of Escherichia coli HypC., Wang L, Xia B, Jin C, Biochem Biophys Res Commun. 2007 Sep 28;361(3):665-9. Epub 2007 Jul 26. PMID:17669368 Page seeded by OCA on Sun May 4 11:36:03 2008

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