This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ot8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2ot8.gif|left|200px]]
[[Image:2ot8.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2ot8 |SIZE=350|CAPTION= <scene name='initialview01'>2ot8</scene>, resolution 3.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_2ot8", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= TNPO1, KPNB2, MIP1, TRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), HNRPM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2ot8| PDB=2ot8 | SCENE= }}
-
|RELATEDENTRY=[[1qbk|1qbk]], [[2h4m|2h4m]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ot8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ot8 OCA], [http://www.ebi.ac.uk/pdbsum/2ot8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ot8 RCSB]</span>
+
-
}}
+
'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''
'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''
Line 27: Line 24:
[[Category: Cansizoglu, A E.]]
[[Category: Cansizoglu, A E.]]
[[Category: Chook, Y M.]]
[[Category: Chook, Y M.]]
-
[[Category: heat repeat]]
+
[[Category: Heat repeat]]
-
[[Category: karyopherin]]
+
[[Category: Karyopherin]]
-
[[Category: nuclear import complex]]
+
[[Category: Nuclear import complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:36:28 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:22:43 2008''
+

Revision as of 08:36, 4 May 2008

Image:2ot8.gif

Template:STRUCTURE 2ot8

Karyopherin Beta2/Transportin-hnRNPM NLS Complex


Overview

Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M.

About this Structure

2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768 Page seeded by OCA on Sun May 4 11:36:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ot8"
Personal tools