2out
From Proteopedia
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'''Solution Structure of HI1506, a Novel Two Domain Protein from Haemophilus influenzae''' | '''Solution Structure of HI1506, a Novel Two Domain Protein from Haemophilus influenzae''' | ||
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[[Category: Schwarz, F.]] | [[Category: Schwarz, F.]] | ||
[[Category: Surabian, K.]] | [[Category: Surabian, K.]] | ||
| - | [[Category: | + | [[Category: Haemophilus influenzae]] |
| - | [[Category: | + | [[Category: Hypothetical protein]] |
| - | [[Category: | + | [[Category: Nmr]] |
| - | [[Category: | + | [[Category: S2f]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Structure 2 function project]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:42:13 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:42, 4 May 2008
Solution Structure of HI1506, a Novel Two Domain Protein from Haemophilus influenzae
Overview
HI1506 is a 128-residue hypothetical protein of unknown function from Haemophilus influenzae. It was originally annotated as a shorter 85-residue protein, but a more detailed sequence analysis conducted in our laboratory revealed that the full-length protein has an additional 43 residues on the C terminus, corresponding with a region initially ascribed to HI1507. As part of a larger effort to understand the functions of hypothetical proteins from Gram-negative bacteria, and H. influenzae in particular, we report here the three-dimensional solution NMR structure for the corrected full-length HI1506 protein. The structure consists of two well-defined domains, an alpha/beta 50-residue N-domain and a 3-alpha 32-residue C-domain, separated by an unstructured 30-residue linker. Both domains have positively charged surface patches and weak structural homology with folds that are associated with RNA binding, suggesting a possible functional role in binding distal nucleic acid sites.
About this Structure
2OUT is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.
Reference
Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae., Sari N, He Y, Doseeva V, Surabian K, Ramprakash J, Schwarz F, Herzberg O, Orban J, Protein Sci. 2007 May;16(5):977-82. Epub 2007 Mar 30. PMID:17400915 Page seeded by OCA on Sun May 4 11:42:13 2008
