2ovc

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[[Image:2ovc.gif|left|200px]]
[[Image:2ovc.gif|left|200px]]
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{{Structure
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|PDB= 2ovc |SIZE=350|CAPTION= <scene name='initialview01'>2ovc</scene>, resolution 2.070&Aring;
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The line below this paragraph, containing "STRUCTURE_2ovc", creates the "Structure Box" on the page.
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|GENE= KCNQ4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2ovc| PDB=2ovc | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ovc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovc OCA], [http://www.ebi.ac.uk/pdbsum/2ovc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ovc RCSB]</span>
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'''Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels'''
'''Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels'''
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[[Category: Howard, R J.]]
[[Category: Howard, R J.]]
[[Category: Minor, D L.]]
[[Category: Minor, D L.]]
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[[Category: coiled-coil]]
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[[Category: Coiled-coil]]
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[[Category: ion channel assembly]]
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[[Category: Ion channel assembly]]
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[[Category: potassium channel]]
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[[Category: Potassium channel]]
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[[Category: tetramer]]
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[[Category: Tetramer]]
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[[Category: voltage-gated channel]]
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[[Category: Voltage-gated channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:23:41 2008''
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Revision as of 08:44, 4 May 2008

Image:2ovc.gif

Template:STRUCTURE 2ovc

Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels


Contents

Overview

Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory I(Ks) current and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail. Here, we present the high-resolution structure of the Kv7.4 A-domain Tail together with biochemical experiments that show that the domain is a self-assembling, parallel, four-stranded coiled coil. Structural analysis and biochemical studies indicate conservation of the coiled coil in all Kv7 subtypes and that a limited set of interactions encode assembly specificity determinants. Kv7 mutations have prominent roles in arrhythmias, deafness, and epilepsy. The structure together with biochemical data indicate that A-domain Tail arrhythmia mutations cluster on the solvent-accessible surface of the subunit interface at a likely site of action for modulatory proteins. Together, the data provide a framework for understanding Kv7 assembly specificity and the molecular basis of a distinct set of Kv7 channelopathies.

Disease

Known disease associated with this structure: Deafness, autosomal dominant 2 OMIM:[603537]

About this Structure

2OVC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insight into KCNQ (Kv7) channel assembly and channelopathy., Howard RJ, Clark KA, Holton JM, Minor DL Jr, Neuron. 2007 Mar 1;53(5):663-75. PMID:17329207 Page seeded by OCA on Sun May 4 11:44:15 2008

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