2ow3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2ow3.jpg|left|200px]]
[[Image:2ow3.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2ow3 |SIZE=350|CAPTION= <scene name='initialview01'>2ow3</scene>, resolution 2.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_2ow3", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Bim+Binding+Site+For+Residue+A+387'>AC1</scene> and <scene name='pdbsite=AC2:Bim+Binding+Site+For+Residue+B+387'>AC2</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BIM:BIS-(INDOLE)MALEIMIDE+PYRIDINOPHANE'>BIM</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= GSK3B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2ow3| PDB=2ow3 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ow3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow3 OCA], [http://www.ebi.ac.uk/pdbsum/2ow3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ow3 RCSB]</span>
+
-
}}
+
'''Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor'''
'''Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor'''
Line 25: Line 22:
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
-
[[Category: [Tau protein] kinase]]
 
[[Category: Bonaga, L V.]]
[[Category: Bonaga, L V.]]
[[Category: Damiano, B P.]]
[[Category: Damiano, B P.]]
Line 32: Line 28:
[[Category: Ye, H.]]
[[Category: Ye, H.]]
[[Category: Zhang, H C.]]
[[Category: Zhang, H C.]]
-
[[Category: kinase-inhibitor complex]]
+
[[Category: Kinase-inhibitor complex]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:46:58 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:24:00 2008''
+

Revision as of 08:46, 4 May 2008

Image:2ow3.jpg

Template:STRUCTURE 2ow3

Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor


Overview

Novel bis(indolyl)maleimide pyridinophanes 3, 9a, 9b, 10a, 10b, and 11 were prepared by cobalt-mediated [2+2+2] cycloaddition of an appropriate alpha,omega-diyne with an N,N-dialkylcyanamide. These macrocyclic heterophanes were found to be potent, selective inhibitors of glycogen synthase kinase-3beta. An X-ray structure of a co-crystal of GSK-3beta and 3 (IC(50)=3nM) depicts the hydrogen bonding and hydrophobic interactions in the ATP-binding pocket of this serine/threonine protein kinase.

About this Structure

2OW3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3., Zhang HC, Bonaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE, Bioorg Med Chem Lett. 2007 May 15;17(10):2863-8. Epub 2007 Feb 25. PMID:17350261 Page seeded by OCA on Sun May 4 11:46:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ow3"
Personal tools