2oyv
From Proteopedia
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[[Image:2oyv.jpg|left|200px]] | [[Image:2oyv.jpg|left|200px]] | ||
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'''Neurotensin in DPC micelles''' | '''Neurotensin in DPC micelles''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYV OCA]. | |
==Reference== | ==Reference== | ||
NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition., Coutant J, Curmi PA, Toma F, Monti JP, Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17441729 17441729] | NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition., Coutant J, Curmi PA, Toma F, Monti JP, Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17441729 17441729] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Coutant, J.]] | [[Category: Coutant, J.]] | ||
[[Category: Curmi, P A.]] | [[Category: Curmi, P A.]] | ||
[[Category: Monti, J P.]] | [[Category: Monti, J P.]] | ||
| - | [[Category: | + | [[Category: Type i turn]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:57:28 2008'' | |
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Revision as of 08:57, 4 May 2008
Neurotensin in DPC micelles
Overview
Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.
About this Structure
Full crystallographic information is available from OCA.
Reference
NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition., Coutant J, Curmi PA, Toma F, Monti JP, Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:17441729 Page seeded by OCA on Sun May 4 11:57:28 2008
