2ozo

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[[Image:2ozo.jpg|left|200px]]
[[Image:2ozo.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ozo |SIZE=350|CAPTION= <scene name='initialview01'>2ozo</scene>, resolution 2.600&Aring;
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The line below this paragraph, containing "STRUCTURE_2ozo", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ZAP70, SRK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2ozo| PDB=2ozo | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ozo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ozo OCA], [http://www.ebi.ac.uk/pdbsum/2ozo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ozo RCSB]</span>
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}}
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'''Autoinhibited intact human ZAP-70'''
'''Autoinhibited intact human ZAP-70'''
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[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
[[Category: Weiss, A.]]
[[Category: Weiss, A.]]
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[[Category: autoinhibition]]
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[[Category: Autoinhibition]]
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[[Category: hydrogen bonding network]]
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[[Category: Hydrogen bonding network]]
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[[Category: inactive zap-70]]
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[[Category: Inactive zap-70]]
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[[Category: itam]]
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[[Category: Itam]]
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[[Category: tandem sh2]]
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[[Category: Tandem sh2]]
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[[Category: tcr signaling]]
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[[Category: Tcr signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:00:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:25:39 2008''
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Revision as of 09:00, 4 May 2008

Image:2ozo.jpg

Template:STRUCTURE 2ozo

Autoinhibited intact human ZAP-70


Overview

ZAP-70, a cytoplasmic tyrosine kinase required for T cell antigen receptor signaling, is controlled by a regulatory segment that includes a tandem SH2 unit responsible for binding to immunoreceptor tyrosine-based activation motifs (ITAMs). The crystal structure of autoinhibited ZAP-70 reveals that the inactive kinase domain adopts a conformation similar to that of cyclin-dependent kinases and Src kinases. The autoinhibitory mechanism of ZAP-70 is, however, distinct and involves interactions between the regulatory segment and the hinge region of the kinase domain that reduce its flexibility. Two tyrosine residues in the SH2-kinase linker that activate ZAP-70 when phosphorylated are involved in aromatic-aromatic interactions that connect the linker to the kinase domain. These interactions are inconsistent with ITAM binding, suggesting that destabilization of this autoinhibited ZAP-70 conformation is the first step in kinase activation.

About this Structure

2OZO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of tyrosine kinase activity of ZAP-70., Deindl S, Kadlecek TA, Brdicka T, Cao X, Weiss A, Kuriyan J, Cell. 2007 May 18;129(4):735-46. PMID:17512407 Page seeded by OCA on Sun May 4 12:00:24 2008

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OCA

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