2p0c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2p0c.jpg|left|200px]]
[[Image:2p0c.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2p0c |SIZE=350|CAPTION= <scene name='initialview01'>2p0c</scene>, resolution 2.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_2p0c", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= MERTK, MER ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2p0c| PDB=2p0c | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0c OCA], [http://www.ebi.ac.uk/pdbsum/2p0c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p0c RCSB]</span>
+
-
}}
+
'''Catalytic Domain of the Proto-oncogene Tyrosine-protein Kinase MER'''
'''Catalytic Domain of the Proto-oncogene Tyrosine-protein Kinase MER'''
Line 36: Line 33:
[[Category: Walker, J R.]]
[[Category: Walker, J R.]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
-
[[Category: atp-binding]]
+
[[Category: Atp-binding]]
-
[[Category: disease mutation]]
+
[[Category: Disease mutation]]
-
[[Category: glycoprotein]]
+
[[Category: Glycoprotein]]
-
[[Category: kinase]]
+
[[Category: Kinase]]
-
[[Category: nucleotide-binding]]
+
[[Category: Nucleotide-binding]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: proto-oncogene]]
+
[[Category: Proto-oncogene]]
-
[[Category: receptor]]
+
[[Category: Receptor]]
-
[[Category: retinitis pigmentosa]]
+
[[Category: Retinitis pigmentosa]]
-
[[Category: sensory transduction]]
+
[[Category: Sensory transduction]]
-
[[Category: sgc]]
+
[[Category: Sgc]]
-
[[Category: signal]]
+
[[Category: Signal]]
-
[[Category: structural genomic]]
+
[[Category: Structural genomic]]
-
[[Category: structural genomics consortium]]
+
[[Category: Structural genomics consortium]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
[[Category: tyrosine-protein kinase]]
+
[[Category: Tyrosine-protein kinase]]
-
[[Category: vision]]
+
[[Category: Vision]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:03:13 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:26:08 2008''
+

Revision as of 09:03, 4 May 2008

Image:2p0c.jpg

Template:STRUCTURE 2p0c

Catalytic Domain of the Proto-oncogene Tyrosine-protein Kinase MER


Overview

A human B-lymphoblastoid lambda gt11 expression library was screened using anti-phosphotyrosine antibodies yielding complementary DNAs encoding active tyrosine kinases. The resulting clones were used to obtain the sequence of a novel 984 amino acid transmembrane tyrosine kinase. Analysis of the complementary DNA revealed extracellular immunoglobulin and fibronectin type III domains and the unusual kinase signature sequence KWIAIES; all are characteristic of the axl family of tyrosine kinases. The novel tyrosine kinase was not expressed in normal B- and T-lymphocytes but, unlike axl, was expressed in numerous neoplastic B- and T-cell lines. Transcripts for the novel receptor-like tyrosine kinase were detected in normal peripheral blood monocytes and bone marrow. One alternatively spliced transcript was detected which contained an insert in the membrane proximal region that could encode for a truncated, soluble receptor. Sequence comparison shows that the kinase may be the human protooncogene for the recently isolated chicken retroviral oncogene v-ryk (recently renamed v-eyk), a truncated tyrosine kinase whose expression by retroviral infection produced sarcomas in chickens. The intracellular domain of the human kinase shows 83% similarity and 71% identity to v-ryk. Since the ryk designation has been used to name another tyrosine kinase and an analysis of RNA expression demonstrated that this novel human kinase is expressed in monocytes and tissues of epithelial and reproductive origin, we have designated our novel protooncogene c-mer.

About this Structure

2P0C is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Cloning and mRNA expression analysis of a novel human protooncogene, c-mer., Graham DK, Dawson TL, Mullaney DL, Snodgrass HR, Earp HS, Cell Growth Differ. 1994 Jun;5(6):647-57. PMID:8086340 Page seeded by OCA on Sun May 4 12:03:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2p0c"
Personal tools