2p0e

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[[Image:2p0e.jpg|left|200px]]
[[Image:2p0e.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2p0e |SIZE=350|CAPTION= <scene name='initialview01'>2p0e</scene>, resolution 1.800&Aring;
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The line below this paragraph, containing "STRUCTURE_2p0e", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TIZ:(1R)-1-[4-(AMINOCARBONYL)-1,3-THIAZOL-2-YL]-1,4-ANHYDRO-D-RIBITOL'>TIZ</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NRK1, C9orf95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2p0e| PDB=2p0e | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0e OCA], [http://www.ebi.ac.uk/pdbsum/2p0e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p0e RCSB]</span>
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}}
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'''Human nicotinamide riboside kinase 1 in complex with tiazofurin'''
'''Human nicotinamide riboside kinase 1 in complex with tiazofurin'''
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[[Category: Tempel, W.]]
[[Category: Tempel, W.]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
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[[Category: adp]]
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[[Category: Adp]]
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[[Category: nad+]]
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[[Category: Nad+]]
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[[Category: nicotinamide riboside]]
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[[Category: Nicotinamide riboside]]
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[[Category: non-protein kinase]]
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[[Category: Non-protein kinase]]
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[[Category: nrk1]]
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[[Category: Nrk1]]
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[[Category: sgc]]
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[[Category: Sgc]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural genomics consortium]]
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[[Category: Structural genomics consortium]]
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[[Category: tiazofurin]]
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[[Category: Tiazofurin]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:03:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:26:08 2008''
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Revision as of 09:03, 4 May 2008

Image:2p0e.jpg

Template:STRUCTURE 2p0e

Human nicotinamide riboside kinase 1 in complex with tiazofurin


Overview

The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and adenylylation. Crystal structures of human Nrk1 bound to nucleoside and nucleotide substrates and products revealed an enzyme structurally similar to Rossmann fold metabolite kinases and allowed the identification of active site residues, which were shown to be essential for human Nrk1 and Nrk2 activity in vivo. Although the structures account for the 500-fold discrimination between nicotinamide riboside and pyrimidine nucleosides, no enzyme feature was identified to recognize the distinctive carboxamide group of nicotinamide riboside. Indeed, nicotinic acid riboside is a specific substrate of human Nrk enzymes and is utilized in yeast in a novel biosynthetic pathway that depends on Nrk and NAD+ synthetase. Additionally, nicotinic acid riboside is utilized in vivo by Urh1, Pnp1, and Preiss-Handler salvage. Thus, crystal structures of Nrk1 led to the identification of new pathways to NAD+.

About this Structure

2P0E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Nicotinamide riboside kinase structures reveal new pathways to NAD+., Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C, PLoS Biol. 2007 Oct 2;5(10):e263. PMID:17914902 Page seeded by OCA on Sun May 4 12:03:34 2008

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OCA

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