2p1o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2p1o.gif|left|200px]]
[[Image:2p1o.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2p1o |SIZE=350|CAPTION= <scene name='initialview01'>2p1o</scene>, resolution 1.90&Aring;
+
The line below this paragraph, containing "STRUCTURE_2p1o", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=NLA:NAPHTHALEN-1-YL-ACETIC+ACID'>NLA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= SKP1A, ASK1, SKP1, UIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana]), TIR1, FBL1, WEI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2p1o| PDB=2p1o | SCENE= }}
-
|RELATEDENTRY=[[2p1m|2P1M]], [[2p1n|2P1N]], [[2p1p|2P1P]], [[2p1q|2P1Q]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1o OCA], [http://www.ebi.ac.uk/pdbsum/2p1o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p1o RCSB]</span>
+
-
}}
+
'''Mechanism of Auxin Perception by the TIR1 ubiquitin ligase'''
'''Mechanism of Auxin Perception by the TIR1 ubiquitin ligase'''
Line 31: Line 28:
[[Category: Tan, X.]]
[[Category: Tan, X.]]
[[Category: Zheng, N.]]
[[Category: Zheng, N.]]
-
[[Category: f-box]]
+
[[Category: F-box]]
-
[[Category: leucine rich repeat]]
+
[[Category: Leucine rich repeat]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:09:22 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:27:04 2008''
+

Revision as of 09:09, 4 May 2008

Image:2p1o.gif

Template:STRUCTURE 2p1o

Mechanism of Auxin Perception by the TIR1 ubiquitin ligase


Overview

Auxin is a pivotal plant hormone that controls many aspects of plant growth and development. Perceived by a small family of F-box proteins including transport inhibitor response 1 (TIR1), auxin regulates gene expression by promoting SCF ubiquitin-ligase-catalysed degradation of the Aux/IAA transcription repressors, but how the TIR1 F-box protein senses and becomes activated by auxin remains unclear. Here we present the crystal structures of the Arabidopsis TIR1-ASK1 complex, free and in complexes with three different auxin compounds and an Aux/IAA substrate peptide. These structures show that the leucine-rich repeat domain of TIR1 contains an unexpected inositol hexakisphosphate co-factor and recognizes auxin and the Aux/IAA polypeptide substrate through a single surface pocket. Anchored to the base of the TIR1 pocket, auxin binds to a partially promiscuous site, which can also accommodate various auxin analogues. Docked on top of auxin, the Aux/IAA substrate peptide occupies the rest of the TIR1 pocket and completely encloses the hormone-binding site. By filling in a hydrophobic cavity at the protein interface, auxin enhances the TIR1-substrate interactions by acting as a 'molecular glue'. Our results establish the first structural model of a plant hormone receptor.

About this Structure

2P1O is a Protein complex structure of sequences from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Mechanism of auxin perception by the TIR1 ubiquitin ligase., Tan X, Calderon-Villalobos LI, Sharon M, Zheng C, Robinson CV, Estelle M, Zheng N, Nature. 2007 Apr 5;446(7136):640-5. PMID:17410169 Page seeded by OCA on Sun May 4 12:09:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2p1o"
Personal tools