2p3m

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[[Image:2p3m.jpg|left|200px]]
[[Image:2p3m.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2p3m |SIZE=350|CAPTION= <scene name='initialview01'>2p3m</scene>
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The line below this paragraph, containing "STRUCTURE_2p3m", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_kinase Riboflavin kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.26 2.7.1.26] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Mj0056 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
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|DOMAIN=
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{{STRUCTURE_2p3m| PDB=2p3m | SCENE= }}
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|RELATEDENTRY=[[2vbs|2VBS]], [[2vbu|2VBU]], [[2vbt|2VBT]], [[2vbv|2VBV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p3m OCA], [http://www.ebi.ac.uk/pdbsum/2p3m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p3m RCSB]</span>
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}}
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'''Solution structure of Mj0056'''
'''Solution structure of Mj0056'''
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[[Category: Martin, J.]]
[[Category: Martin, J.]]
[[Category: Truffault, V.]]
[[Category: Truffault, V.]]
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[[Category: phosphotransferase]]
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[[Category: Phosphotransferase]]
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[[Category: riboflavin kinase]]
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[[Category: Riboflavin kinase]]
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[[Category: rift barrel]]
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[[Category: Rift barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:16:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:28:37 2008''
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Revision as of 09:16, 4 May 2008

Image:2p3m.jpg

Template:STRUCTURE 2p3m

Solution structure of Mj0056


Overview

Proteins of the cradle-loop barrel metafold are formed by duplication of a conserved betaalphabeta-element, suggesting a common evolutionary origin from an ancestral group of nucleic acid-binding proteins. The basal fold within this metafold, the RIFT barrel, is also found in a wide range of enzymes, whose homologous relationship with the nucleic acid-binding group is unclear. We have characterized a protein family that is intermediate in sequence and structure between the basal group of cradle-loop barrels and one family of RIFT-barrel enzymes, the riboflavin kinases. We report the structure, substrate-binding mode, and catalytic activity for one of these proteins, Methanocaldococcus jannaschii Mj0056, which is an archaeal riboflavin kinase. Mj0056 is unusual in utilizing CTP rather than ATP as the donor nucleotide, and sequence conservation in the relevant residues suggests that this is a general feature of archaeal riboflavin kinases.

About this Structure

2P3M is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

A CTP-dependent archaeal riboflavin kinase forms a bridge in the evolution of cradle-loop barrels., Ammelburg M, Hartmann MD, Djuranovic S, Alva V, Koretke KK, Martin J, Sauer G, Truffault V, Zeth K, Lupas AN, Coles M, Structure. 2007 Dec;15(12):1577-90. PMID:18073108 Page seeded by OCA on Sun May 4 12:16:39 2008

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