2p3v

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[[Image:2p3v.gif|left|200px]]
[[Image:2p3v.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2p3v |SIZE=350|CAPTION= <scene name='initialview01'>2p3v</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_2p3v", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= suhB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
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-->
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|DOMAIN=
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{{STRUCTURE_2p3v| PDB=2p3v | SCENE= }}
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|RELATEDENTRY=[[2p3n|2P3N]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p3v OCA], [http://www.ebi.ac.uk/pdbsum/2p3v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p3v RCSB]</span>
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}}
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'''Thermotoga maritima IMPase TM1415'''
'''Thermotoga maritima IMPase TM1415'''
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[[Category: Stec, B.]]
[[Category: Stec, B.]]
[[Category: Stieglitz, K A.]]
[[Category: Stieglitz, K A.]]
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[[Category: asymmetric tetramer]]
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[[Category: Asymmetric tetramer]]
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[[Category: inositol]]
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[[Category: Inositol]]
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[[Category: phosphatase]]
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[[Category: Phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:17:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:28:50 2008''
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Revision as of 09:17, 4 May 2008

Image:2p3v.gif

Template:STRUCTURE 2p3v

Thermotoga maritima IMPase TM1415


Overview

The structure of the first tetrameric inositol monophosphatase (IMPase) has been solved. This enzyme, from the eubacterium Thermotoga maritima, similarly to its archaeal homologs exhibits dual specificity with both IMPase and fructose-1,6-bisphosphatase activities. The tetrameric structure of this unregulated enzyme is similar, in its quaternary assembly, to the allosterically regulated tetramer of fructose-1,6-bisphosphatase. The individual dimers are similar to the human IMPase. Additionally, the structures of two crystal forms of IMPase show significant differences. In the first crystal form, the tetrameric structure is symmetrical, with the active site loop in each subunit folded into a beta-hairpin conformation. The second form is asymmetrical and shows an unusual structural change. Two of the subunits have the active site loop folded into a beta-hairpin structure, whereas in the remaining two subunits the same loop adopts an alpha-helical conformation.

About this Structure

2P3V is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima., Stieglitz KA, Roberts MF, Li W, Stec B, FEBS J. 2007 May;274(10):2461-9. Epub 2007 Apr 10. PMID:17419729 Page seeded by OCA on Sun May 4 12:17:42 2008

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