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1f4x
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(New page: 200px<br /> <applet load="1f4x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f4x, resolution 2.3Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 07:22, 18 November 2007
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CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN
Overview
The crystal structure of the murine Fab S-20-4 from a protective, anti-cholera Ab specific for the lipopolysaccharide Ag of the Ogawa, serotype has been determined in its unliganded form and in complex with, synthetic fragments of the Ogawa O-specific polysaccharide (O-SP). The, upstream terminal O-SP monosaccharide is shown to be the primary antigenic, determinant. Additional perosamine residues protrude outwards from the Ab, surface and contribute only marginally to the binding affinity and, specificity. A complementary water-excluding hydrophobic interface and, five Ab-Ag hydrogen bonds are crucial for carbohydrate recognition. The, structure reported here explains the serotype specificity of anti-Ogawa, Abs and provides a rational basis toward the development of a synthetic, carbohydrate-based anti-cholera vaccine.
About this Structure
1F4X is a Protein complex structure of sequences from Mus musculus with MGS as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity., Villeneuve S, Souchon H, Riottot MM, Mazie JC, Lei P, Glaudemans CP, Kovac P, Fournier JM, Alzari PM, Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8433-8. PMID:10880560
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