2p6b

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[[Image:2p6b.jpg|left|200px]]
[[Image:2p6b.jpg|left|200px]]
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{{Structure
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|PDB= 2p6b |SIZE=350|CAPTION= <scene name='initialview01'>2p6b</scene>, resolution 2.300&Aring;
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The line below this paragraph, containing "STRUCTURE_2p6b", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= PPP3CA, CALNA, CNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PPP3R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2p6b| PDB=2p6b | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p6b OCA], [http://www.ebi.ac.uk/pdbsum/2p6b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p6b RCSB]</span>
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'''Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide'''
'''Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide'''
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[[Category: Rao, A.]]
[[Category: Rao, A.]]
[[Category: Zhang, L.]]
[[Category: Zhang, L.]]
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[[Category: beta-sheet augmentation]]
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[[Category: Beta-sheet augmentation]]
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[[Category: protein-peptide complex]]
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[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:28:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:30:32 2008''
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Revision as of 09:28, 4 May 2008

Image:2p6b.jpg

Template:STRUCTURE 2p6b

Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide


Overview

The protein phosphatase calcineurin recognizes a wide assortment of substrates and controls diverse developmental and physiological pathways in eukaryotic cells. Dephosphorylation of the transcription factor NFAT and certain other calcineurin substrates depends on docking of calcineurin at a PxIxIT consensus site. We describe here the structural basis for recognition of the PxIxIT sequence by calcineurin. We demonstrate that the high-affinity peptide ligand PVIVIT adds as a beta-strand to the edge of a beta-sheet of calcineurin; that short peptide segments containing the PxIxIT consensus sequence suffice for calcineurin-substrate docking; and that sequence variations within the PxIxIT core modulate the K(d) of the interaction within the physiological range 1 microM to 1 mM. Calcineurin can adapt to a wide variety of substrates, because recognition requires only a PxIxIT sequence and because variation within the core PxIxIT sequence can fine-tune the affinity to match the physiological signalling requirements of individual substrates.

About this Structure

2P6B is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction., Li H, Zhang L, Rao A, Harrison SC, Hogan PG, J Mol Biol. 2007 Jun 22;369(5):1296-306. Epub 2007 Apr 19. PMID:17498738 Page seeded by OCA on Sun May 4 12:28:14 2008

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