2p73

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[[Image:2p73.jpg|left|200px]]
[[Image:2p73.jpg|left|200px]]
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{{Structure
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|PDB= 2p73 |SIZE=350|CAPTION= <scene name='initialview01'>2p73</scene>, resolution 2.300&Aring;
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The line below this paragraph, containing "STRUCTURE_2p73", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5&#39;-DIPHOSPHATE'>UDP</scene>
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|GENE= A64R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10506 Paramecium bursaria Chlorella virus 1])
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|DOMAIN=
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{{STRUCTURE_2p73| PDB=2p73 | SCENE= }}
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|RELATEDENTRY=[[2p6w|2P6W]], [[2p72|2P72]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p73 OCA], [http://www.ebi.ac.uk/pdbsum/2p73 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p73 RCSB]</span>
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'''crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1'''
'''crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1'''
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[[Category: Xiang, Y.]]
[[Category: Xiang, Y.]]
[[Category: Zhang, Y.]]
[[Category: Zhang, Y.]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: glycosyltransferase]]
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[[Category: Glycosyltransferase]]
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[[Category: pbcv-1 a64r]]
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[[Category: Pbcv-1 a64r]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:31:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:31:12 2008''
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Revision as of 09:31, 4 May 2008

Image:2p73.jpg

Template:STRUCTURE 2p73

crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1


Overview

Paramecium bursaria chlorella virus-1 encodes at least five putative glycosyltransferases that are probably involved in the synthesis of the glycan components of the viral major capsid protein. The 1.6 A crystal structure of one of these glycosyltransferases (A64R) has a mixed alpha/beta fold containing a central, six-stranded beta sheet flanked by alpha helices. Crystal structures of A64R, complexed with UDP, CMP, or GDP, established that only UDP bound to A64R in the presence of Mn(2+), consistent with its high structural similarity to glycosyltransferases which utilize UDP as the sugar carrier. The structure of the complex of A64R, UDP-glucose, and Mn(2+) showed that the largest conformational change occurred when hydrogen bonds were formed with the ligands. Unlike UDP-glucose, UDP-galactose and UDP-GlcNAc did not bind to A64R, suggesting a selective binding of UDP-glucose. Thus, UDP-glucose is most likely the sugar donor for A64R, consistent with glucose occurring in the virus major capsid protein glycans.

About this Structure

2P73 is a Single protein structure of sequence from Paramecium bursaria chlorella virus 1. Full crystallographic information is available from OCA.

Reference

Structure and function of a chlorella virus-encoded glycosyltransferase., Zhang Y, Xiang Y, Van Etten JL, Rossmann MG, Structure. 2007 Sep;15(9):1031-9. PMID:17850743 Page seeded by OCA on Sun May 4 12:31:24 2008

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