1h3p
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(New page: 200px<br /> <applet load="1h3p" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h3p, resolution 2.6Å" /> '''STRUCTURAL CHARACTER...)
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Revision as of 07:24, 18 November 2007
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STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS
Overview
The monoclonal antibody 5a19, raised against the ay serotype of hepatitis, B virus, binds to the segment of the preS1 region comprising residues, 37-43, which is implicated in attachment of the virus to hepatocytes. The, dissociation constant, derived from kinetic studies using surface plasmon, resonance techniques, is in the low nanomolar range. The nucleotide, sequence of the variable domains has been determined and the corresponding, germ-line genes have been identified. The three-dimensional structure of, the Fab fragment has been determined by X-ray crystallography to 2.6 A, resolution.
About this Structure
1H3P is a Single protein structure of sequence from Mus musculus. This structure superseeds the now removed PDB entry 1GM3. Full crystallographic information is available from OCA.
Reference
Structural and functional characterization of a monoclonal antibody specific for the preS1 region of hepatitis B virus., Pizarro JC, Vulliez-le Normand B, Riottot MM, Budkowska A, Bentley GA, FEBS Lett. 2001 Dec 14;509(3):463-8. PMID:11749974
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