2pa2
From Proteopedia
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'''Crystal structure of human Ribosomal protein L10 core domain''' | '''Crystal structure of human Ribosomal protein L10 core domain''' | ||
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[[Category: Yokoyama, S.]] | [[Category: Yokoyama, S.]] | ||
[[Category: Yoshida, T.]] | [[Category: Yoshida, T.]] | ||
| - | [[Category: | + | [[Category: National project on protein structural and functional analyse]] |
| - | [[Category: | + | [[Category: Nppsfa]] |
| - | [[Category: | + | [[Category: Qm protein]] |
| - | [[Category: | + | [[Category: Ribosomal protein l10]] |
| - | [[Category: | + | [[Category: Riken structural genomics/proteomics initiative]] |
| - | [[Category: | + | [[Category: Rsgi]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:42:07 2008'' | |
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Revision as of 09:42, 4 May 2008
Crystal structure of human Ribosomal protein L10 core domain
Overview
A phylogenetically conserved ribosomal protein L16p/L10e organizes the architecture of the aminoacyl tRNA binding site on the large ribosomal subunit. Eukaryotic L10 also exhibits a variety of cellular activities, and, in particular, human L10 is known as a putative tumor suppressor, QM. We have determined the 2.5-A crystal structure of the human L10 core domain that corresponds to residues 34-182 of the full-length 214 amino acids. Its two-layered alpha+beta architecture is significantly similar to those of the archaeal and bacterial homologues, substantiating a high degree of structural conservation across the three phylogenetic domains. A cation-binding pocket formed between alpha2 and beta 6 is similar to that of the archaeal L10 protein but appears to be better ordered. Previously reported L10 mutations that cause defects in the yeast ribosome are clustered around this pocket, indicating that its integrity is crucial for its role in L10 function. Characteristic interactions among Arg90-Trp171-Arg139 guide the C-terminal part outside of the central fold, implying that the eukaryote-specific C-terminal extension localizes on the outer side of the ribosome.
About this Structure
2PA2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold., Nishimura M, Kaminishi T, Takemoto C, Kawazoe M, Yoshida T, Tanaka A, Sugano S, Shirouzu M, Ohkubo T, Yokoyama S, Kobayashi Y, J Mol Biol. 2008 Mar 21;377(2):421-30. Epub 2008 Jan 11. PMID:18258260 Page seeded by OCA on Sun May 4 12:42:07 2008
Categories: Homo sapiens | Single protein | Kaminishi, T. | Kawazoe, M. | Kobayashi, Y. | Nishimura, M. | Ohkubo, T. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Shirouzu, M. | Sugano, S. | Takemoto, C. | Tanaka, A. | Yokoyama, S. | Yoshida, T. | National project on protein structural and functional analyse | Nppsfa | Qm protein | Ribosomal protein l10 | Riken structural genomics/proteomics initiative | Rsgi | Structural genomic
