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2pbh

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[[Image:2pbh.gif|left|200px]]
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{{Structure
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|PDB= 2pbh |SIZE=350|CAPTION= <scene name='initialview01'>2pbh</scene>, resolution 3.3&Aring;
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The line below this paragraph, containing "STRUCTURE_2pbh", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pbh OCA], [http://www.ebi.ac.uk/pdbsum/2pbh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pbh RCSB]</span>
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'''CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION'''
'''CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION'''
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[[Category: Turk, D.]]
[[Category: Turk, D.]]
[[Category: Turk, V.]]
[[Category: Turk, V.]]
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[[Category: cathepsin b]]
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[[Category: Cathepsin b]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: cysteine protease]]
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[[Category: Cysteine protease]]
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[[Category: papain]]
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[[Category: Papain]]
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[[Category: proenzyme]]
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[[Category: Proenzyme]]
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[[Category: thiol protease]]
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[[Category: Thiol protease]]
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Revision as of 09:46, 4 May 2008

Image:2pbh.gif

Template:STRUCTURE 2pbh

CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION


Overview

A wild-type human procathepsin B was expressed, crystallized in two crystal forms and its crystal structure determined at 3.2 and 3.3 Angstroms resolution. The structure reveals that the propeptide folds on the cathepsin B surface, shielding the enzyme active site from exposure to solvent. The structure of the enzymatically active domains is virtually identical to that of the native enzyme [Musil et al. (1991) EMBO J. 10, 2321-2330]: the main difference is that the occluding loop residues are lifted above the body of the mature enzyme, supporting the propeptide structure.

About this Structure

2PBH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide., Turk D, Podobnik M, Kuhelj R, Dolinar M, Turk V, FEBS Lett. 1996 Apr 22;384(3):211-4. PMID:8617355 Page seeded by OCA on Sun May 4 12:46:51 2008

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