2pd8
From Proteopedia
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| - | + | {{STRUCTURE_2pd8| PDB=2pd8 | SCENE= }} | |
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'''1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid''' | '''1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid''' | ||
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[[Category: Crane, B R.]] | [[Category: Crane, B R.]] | ||
[[Category: Zoltowski, B D.]] | [[Category: Zoltowski, B D.]] | ||
| - | [[Category: | + | [[Category: Circadian clock]] |
| - | [[Category: | + | [[Category: Flavin]] |
| - | [[Category: | + | [[Category: Lov domain]] |
| - | [[Category: | + | [[Category: Photoreceptor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:53:50 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:53, 4 May 2008
1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid
Overview
The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a light, oxygen, or voltage Per-Arnt-Sim domain with an unusual N-terminal cap region and a loop insertion that accommodates the flavin cofactor. Photoinduced formation of a cystein-flavin adduct drives flavin protonation to induce an N-terminal conformational change. A cysteine-to-serine substitution remote from the flavin adenine dinucleotide binding site decouples conformational switching from the flavin photocycle and prevents Vivid from sending signals in Neurospora. Key elements of this activation mechanism are conserved by other photosensors such as White Collar-1, ZEITLUPE, ENVOY, and flavin-binding, kelch repeat, F-BOX 1 (FKF1).
About this Structure
2PD8 is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.
Reference
Conformational switching in the fungal light sensor Vivid., Zoltowski BD, Schwerdtfeger C, Widom J, Loros JJ, Bilwes AM, Dunlap JC, Crane BR, Science. 2007 May 18;316(5827):1054-7. PMID:17510367 Page seeded by OCA on Sun May 4 12:53:50 2008
