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2phw

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[[Image:2phw.jpg|left|200px]]
[[Image:2phw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2phw |SIZE=350|CAPTION= <scene name='initialview01'>2phw</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_2phw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2phw| PDB=2phw | SCENE= }}
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|RELATEDENTRY=[[1q8p|1Q8P]], [[2phf|2PHF]], [[2phr|2PHR]], [[2pht|2PHT]], [[2phu|2PHU]], [[2phx|2PHX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2phw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2phw OCA], [http://www.ebi.ac.uk/pdbsum/2phw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2phw RCSB]</span>
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}}
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'''Pterocarpus angolensis lectin (PAL) in complex with Man-9'''
'''Pterocarpus angolensis lectin (PAL) in complex with Man-9'''
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[[Category: Loris, R.]]
[[Category: Loris, R.]]
[[Category: Wyns, L.]]
[[Category: Wyns, L.]]
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[[Category: carbohydrate]]
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[[Category: Carbohydrate]]
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[[Category: high mannose]]
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[[Category: High mannose]]
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[[Category: lectin]]
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[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:08:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:36:07 2008''
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Revision as of 10:08, 4 May 2008

Image:2phw.jpg

Template:STRUCTURE 2phw

Pterocarpus angolensis lectin (PAL) in complex with Man-9


Overview

The crystal structure of Pterocarpus angolensis seed lectin is presented in complex with a series of high mannose (Man) oligosaccharides ranging from Man-5 to Man-9. Despite that several of the nine Man residues of Man-9 have the potential to bind in the monosaccharide-binding site, all oligomannoses are bound in the same unique way, employing the tetrasaccharide sequence Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-. Isothermal titration calorimetry titration experiments using Man-5, Man-9, and the Man-9-containing glycoprotein soybean (Glycine max) agglutinin as ligands confirm the monovalence of Man-9 and show a 4-times higher affinity for Man-9 when it is presented to P. angolensis seed lectin in a glycoprotein context.

About this Structure

2PHW is a Single protein structure of sequence from Pterocarpus angolensis. Full crystallographic information is available from OCA.

Reference

How a plant lectin recognizes high mannose oligosaccharides., Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R, Plant Physiol. 2007 Aug;144(4):1733-41. Epub 2007 Jun 7. PMID:17556509 Page seeded by OCA on Sun May 4 13:08:35 2008

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