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2pl5

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[[Image:2pl5.jpg|left|200px]]
[[Image:2pl5.jpg|left|200px]]
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{{Structure
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|PDB= 2pl5 |SIZE=350|CAPTION= <scene name='initialview01'>2pl5</scene>, resolution 2.200&Aring;
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The line below this paragraph, containing "STRUCTURE_2pl5", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= metX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=173 Leptospira interrogans])
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|DOMAIN=
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{{STRUCTURE_2pl5| PDB=2pl5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pl5 OCA], [http://www.ebi.ac.uk/pdbsum/2pl5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pl5 RCSB]</span>
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'''Crystal Structure of Homoserine O-acetyltransferase from Leptospira interrogans'''
'''Crystal Structure of Homoserine O-acetyltransferase from Leptospira interrogans'''
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[[Category: Wei, Z.]]
[[Category: Wei, Z.]]
[[Category: Xu, H.]]
[[Category: Xu, H.]]
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[[Category: alpha/beta hydrolase superfamily]]
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[[Category: Alpha/beta hydrolase superfamily]]
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[[Category: homoserine o-acetyltransferase]]
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[[Category: Homoserine o-acetyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:20:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:37:27 2008''
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Revision as of 10:20, 4 May 2008

Image:2pl5.jpg

Template:STRUCTURE 2pl5

Crystal Structure of Homoserine O-acetyltransferase from Leptospira interrogans


Overview

Homoserine O-acetyltransferase (HTA, EC 2.3.1.31) initiates methionine biosynthesis pathway by catalyzing the transfer of acetyl group from acetyl-CoA to homoserine. This study reports the crystal structure of HTA from Leptospira interrogans determined at 2.2A resolution using selenomethionyl single-wavelength anomalous diffraction method. HTA is modular and consists of two structurally distinct domains--a core alpha/beta domain containing the catalytic site and a helical bundle called the lid domain. Overall, the structure fold belongs to alpha/beta hydrolase superfamily with the characteristic 'catalytic triad' residues in the active site. Detailed structure analysis showed that the catalytic histidine and serine are both present in two conformations, which may be involved in the catalytic mechanism for acetyl transfer.

About this Structure

2PL5 is a Single protein structure of sequence from Leptospira interrogans. Full crystallographic information is available from OCA.

Reference

Crystal structure of homoserine O-acetyltransferase from Leptospira interrogans., Wang M, Liu L, Wang Y, Wei Z, Zhang P, Li Y, Jiang X, Xu H, Gong W, Biochem Biophys Res Commun. 2007 Nov 30;363(4):1050-6. Epub 2007 Sep 4. PMID:17927957 Page seeded by OCA on Sun May 4 13:20:14 2008

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