2plb
From Proteopedia
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[[Image:2plb.gif|left|200px]] | [[Image:2plb.gif|left|200px]] | ||
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'''D(GTATACC) under hydrostatic pressure of 1.39 GPa''' | '''D(GTATACC) under hydrostatic pressure of 1.39 GPa''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLB OCA]. | |
==Reference== | ==Reference== | ||
Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17617642 17617642] | Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17617642 17617642] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Fourme, R.]] | [[Category: Fourme, R.]] | ||
[[Category: Girard, E.]] | [[Category: Girard, E.]] | ||
[[Category: Kahn, R.]] | [[Category: Kahn, R.]] | ||
[[Category: Prange, T.]] | [[Category: Prange, T.]] | ||
| - | [[Category: | + | [[Category: Crystal structure]] |
| - | [[Category: | + | [[Category: Dna]] |
| - | [[Category: | + | [[Category: High-pressure]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:21:04 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:21, 4 May 2008
D(GTATACC) under hydrostatic pressure of 1.39 GPa
Overview
The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.
About this Structure
Full crystallographic information is available from OCA.
Reference
Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:17617642 Page seeded by OCA on Sun May 4 13:21:04 2008
