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2pmv

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[[Image:2pmv.gif|left|200px]]
[[Image:2pmv.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pmv OCA], [http://www.ebi.ac.uk/pdbsum/2pmv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pmv RCSB]</span>
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'''Crystal Structure of Human Intrinsic Factor- Cobalamin Complex at 2.6 A Resolution'''
'''Crystal Structure of Human Intrinsic Factor- Cobalamin Complex at 2.6 A Resolution'''
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[[Category: Rajashankar, K R.]]
[[Category: Rajashankar, K R.]]
[[Category: Sukumar, N.]]
[[Category: Sukumar, N.]]
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[[Category: cobalamin transport protein alpha6-alpha6 motif two domain protein]]
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[[Category: Cobalamin transport protein alpha6-alpha6 motif two domain protein]]
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[[Category: transport protein]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:26:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:38:08 2008''
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Revision as of 10:26, 4 May 2008

Image:2pmv.gif

Template:STRUCTURE 2pmv

Crystal Structure of Human Intrinsic Factor- Cobalamin Complex at 2.6 A Resolution


Overview

The structure of intrinsic factor (IF) in complex with cobalamin (Cbl) was determined at 2.6-A resolution. The overall fold of the molecule is that of an alpha(6)/alpha(6) barrel. It is a two-domain protein, and the Cbl is bound at the interface of the domains in a base-on conformation. Surprisingly, two full-length molecules, each comprising an alpha- and a beta-domain and one Cbl, and two truncated molecules with only an alpha- domain are present in the same asymmetric unit. The environment around Cbl is dominated by uncharged residues, and the sixth coordinate position of Co(2+) is empty. A detailed comparison between the IF-B12 complex and another Cbl transport protein complex, trans-Cbl-B12, has been made. The pH effect on the binding of Cbl analogues in transport proteins is analyzed. A possible basis for the lack of interchangeability of human and rat IF receptors is presented.

About this Structure

2PMV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution., Mathews FS, Gordon MM, Chen Z, Rajashankar KR, Ealick SE, Alpers DH, Sukumar N, Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17311-6. Epub 2007 Oct 22. PMID:17954916 Page seeded by OCA on Sun May 4 13:26:32 2008

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