2pmz

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[[Image:2pmz.jpg|left|200px]]
[[Image:2pmz.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2pmz |SIZE=350|CAPTION= <scene name='initialview01'>2pmz</scene>, resolution 3.40&Aring;
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The line below this paragraph, containing "STRUCTURE_2pmz", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+1002'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+A+1003'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Residue+B+2001'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Residue+N+1001'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Residue+P+1001'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Residue+Q+1002'>AC6</scene>, <scene name='pdbsite=AC7:Mg+Binding+Site+For+Residue+Q+1003'>AC7</scene>, <scene name='pdbsite=AC8:Zn+Binding+Site+For+Residue+R+2001'>AC8</scene>, <scene name='pdbsite=AC9:Zn+Binding+Site+For+Residue+Y+1001'>AC9</scene>, <scene name='pdbsite=BC1:Zn+Binding+Site+For+Residue+Z+1001'>BC1</scene>, <scene name='pdbsite=BC2:F3s+Binding+Site+For+Residue+D+1001'>BC2</scene> and <scene name='pdbsite=BC3:F3s+Binding+Site+For+Residue+S+1001'>BC3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2pmz| PDB=2pmz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pmz OCA], [http://www.ebi.ac.uk/pdbsum/2pmz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pmz RCSB]</span>
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}}
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'''Archaeal RNA polymerase from Sulfolobus solfataricus'''
'''Archaeal RNA polymerase from Sulfolobus solfataricus'''
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[[Category: Murakami, K S.]]
[[Category: Murakami, K S.]]
[[Category: 4fe-4s cluster binding motif]]
[[Category: 4fe-4s cluster binding motif]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: translation]]
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[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:26:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:38:14 2008''
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Revision as of 10:26, 4 May 2008

Image:2pmz.jpg

Template:STRUCTURE 2pmz

Archaeal RNA polymerase from Sulfolobus solfataricus


Overview

The transcription apparatus in Archaea can be described as a simplified version of its eukaryotic RNA polymerase (RNAP) II counterpart, comprising an RNAPII-like enzyme as well as two general transcription factors, the TATA-binding protein (TBP) and the eukaryotic TFIIB orthologue TFB. It has been widely understood that precise comparisons of cellular RNAP crystal structures could reveal structural elements common to all enzymes and that these insights would be useful in analysing components of each enzyme that enable it to perform domain-specific gene expression. However, the structure of archaeal RNAP has been limited to individual subunits. Here we report the first crystal structure of the archaeal RNAP from Sulfolobus solfataricus at 3.4 A resolution, completing the suite of multi-subunit RNAP structures from all three domains of life. We also report the high-resolution (at 1.76 A) crystal structure of the D/L subcomplex of archaeal RNAP and provide the first experimental evidence of any RNAP possessing an iron-sulphur (Fe-S) cluster, which may play a structural role in a key subunit of RNAP assembly. The striking structural similarity between archaeal RNAP and eukaryotic RNAPII highlights the simpler archaeal RNAP as an ideal model system for dissecting the molecular basis of eukaryotic transcription.

About this Structure

2PMZ is a Protein complex structure of sequences from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

The X-ray crystal structure of RNA polymerase from Archaea., Hirata A, Klein BJ, Murakami KS, Nature. 2008 Feb 14;451(7180):851-4. Epub 2008 Jan 30. PMID:18235446 Page seeded by OCA on Sun May 4 13:26:53 2008

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