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2pna

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[[Image:2pna.gif|left|200px]]
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{{Structure
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|PDB= 2pna |SIZE=350|CAPTION= <scene name='initialview01'>2pna</scene>
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The line below this paragraph, containing "STRUCTURE_2pna", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span>
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{{STRUCTURE_2pna| PDB=2pna | SCENE= }}
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|RELATEDENTRY=[[2pnb|2PNB]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pna OCA], [http://www.ebi.ac.uk/pdbsum/2pna PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pna RCSB]</span>
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'''STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE'''
'''STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE'''
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[[Category: Panayotou, G.]]
[[Category: Panayotou, G.]]
[[Category: Waterfield, M D.]]
[[Category: Waterfield, M D.]]
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[[Category: signalling protein]]
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[[Category: Signalling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:28:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:38:18 2008''
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Revision as of 10:28, 4 May 2008

Image:2pna.gif

Template:STRUCTURE 2pna

STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE


Overview

Receptor protein-tyrosine kinases, through phosphorylation of specific tyrosine residues, generate high-affinity binding sites which direct assembly of multienzyme signalling complexes. Many of these signalling proteins, including phospholipase C gamma, GTPase-activating protein and phosphatidylinositol-3-OH kinase, contain src-homology 2 (SH2) domains, which bind with high affinity and specificity to tyrosine-phosphorylated sequences. The critical role played by SH2 domains in signalling has been highlighted by recent studies showing that mutation of specific phosphorylation sites on the platelet-derived growth factor receptor impair its association with phosphatidylinositol-3-OH kinase, preventing growth factor-induced mitogenesis. Here we report the solution structure of an isolated SH2 domain from the 85K regulatory subunit of phosphatidylinositol-3-OH kinase, determined using multidimensional nuclear magnetic resonance spectroscopy. The structure is characterized by a central region of beta-sheet flanked by two alpha-helices, with a highly flexible loop close to functionally important residues previously identified by site-directed mutagenesis.

About this Structure

2PNA is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase., Booker GW, Breeze AL, Downing AK, Panayotou G, Gout I, Waterfield MD, Campbell ID, Nature. 1992 Aug 20;358(6388):684-7. PMID:1323062 Page seeded by OCA on Sun May 4 13:28:08 2008

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