2pob

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[[Image:2pob.jpg|left|200px]]
[[Image:2pob.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2pob |SIZE=350|CAPTION= <scene name='initialview01'>2pob</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2pob", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gw4+Binding+Site+For+Residue+A+478'>AC1</scene> and <scene name='pdbsite=AC2:Gol+Binding+Site+For+Residue+B+478'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GW4:N-[(2S)-2-[(2-BENZOYLPHENYL)AMINO]-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL]ACETAMIDE'>GW4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= PPARG, NR1C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2pob| PDB=2pob | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pob OCA], [http://www.ebi.ac.uk/pdbsum/2pob PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pob RCSB]</span>
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}}
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'''PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709'''
'''PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Nolte, R T.]]
[[Category: Nolte, R T.]]
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[[Category: gene regulation]]
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[[Category: Gene regulation]]
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[[Category: nuclear receptor,ppar]]
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[[Category: Nuclear receptor,ppar]]
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[[Category: pparg]]
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[[Category: Pparg]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:31:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:38:38 2008''
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Revision as of 10:31, 4 May 2008

Image:2pob.jpg

Template:STRUCTURE 2pob

PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709


Overview

PPARgamma-activating thiazolidinediones and carboxylic acids such as farglitazar exert their anti-diabetic effects in part in PPARgamma rich adipose. Both pro- and anti-adipogenic PPARgamma ligands promote glucose and lipid lowering in animal models of diabetes. Herein, we disclose representatives of an array of 160 farglitazar analogues with atypical inverse agonism of PPARgamma in mature adipocytes.

About this Structure

2POB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Co-crystal structure guided array synthesis of PPARgamma inverse agonists., Trump RP, Cobb JE, Shearer BG, Lambert MH, Nolte RT, Willson TM, Buckholz RG, Zhao SM, Leesnitzer LM, Iannone MA, Pearce KH, Billin AN, Hoekstra WJ, Bioorg Med Chem Lett. 2007 Jul 15;17(14):3916-20. Epub 2007 May 18. PMID:17533125 Page seeded by OCA on Sun May 4 13:31:47 2008

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OCA

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