2pqt

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[[Image:2pqt.gif|left|200px]]
[[Image:2pqt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2pqt |SIZE=350|CAPTION= <scene name='initialview01'>2pqt</scene>, resolution 1.780&Aring;
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The line below this paragraph, containing "STRUCTURE_2pqt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TYX:S-(2-ANILINO-2-OXOETHYL)-L-CYSTEINE'>TYX</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= NAT1, AAC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2pqt| PDB=2pqt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pqt OCA], [http://www.ebi.ac.uk/pdbsum/2pqt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pqt RCSB]</span>
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}}
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'''Human N-acetyltransferase 1'''
'''Human N-acetyltransferase 1'''
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[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
[[Category: Wu, H.]]
[[Category: Wu, H.]]
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[[Category: arylamide acetylase 1]]
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[[Category: Arylamide acetylase 1]]
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[[Category: arylamine n-acetyltransferase 1]]
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[[Category: Arylamine n-acetyltransferase 1]]
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[[Category: bromoacetanilide]]
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[[Category: Bromoacetanilide]]
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[[Category: covalent]]
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[[Category: Covalent]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: sgc]]
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[[Category: Sgc]]
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[[Category: structural genomics consortium]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:38:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:39:29 2008''
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Revision as of 10:38, 4 May 2008

Image:2pqt.gif

Template:STRUCTURE 2pqt

Human N-acetyltransferase 1


Overview

The human arylamine N-acetyltransferases NAT1 and NAT2 play an important role in the biotransformation of a plethora of aromatic amine and hydrazine drugs. They are also able to participate in the bioactivation of several known carcinogens. Each of these enzymes is genetically variable in human populations, and polymorphisms in NAT genes have been associated with various cancers. Here we have solved the high resolution crystal structures of human NAT1 and NAT2, including NAT1 in complex with the irreversible inhibitor 2-bromoacetanilide, a NAT1 active site mutant, and NAT2 in complex with CoA, and have refined them to 1.7-, 1.8-, and 1.9-A resolution, respectively. The crystal structures reveal novel structural features unique to human NATs and provide insights into the structural basis of the substrate specificity and genetic polymorphism of these enzymes.

About this Structure

2PQT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases., Wu H, Dombrovsky L, Tempel W, Martin F, Loppnau P, Goodfellow GH, Grant DM, Plotnikov AN, J Biol Chem. 2007 Oct 12;282(41):30189-97. Epub 2007 Jul 26. PMID:17656365 Page seeded by OCA on Sun May 4 13:38:50 2008

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OCA

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