2psp

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[[Image:2psp.jpg|left|200px]]
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{{Structure
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{{STRUCTURE_2psp| PDB=2psp | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2psp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2psp OCA], [http://www.ebi.ac.uk/pdbsum/2psp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2psp RCSB]</span>
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'''PORCINE PANCREATIC SPASMOLYTIC POLYPEPTIDE'''
'''PORCINE PANCREATIC SPASMOLYTIC POLYPEPTIDE'''
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[[Category: Henriksen, A.]]
[[Category: Henriksen, A.]]
[[Category: Petersen, T N.]]
[[Category: Petersen, T N.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:44:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:40:11 2008''
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Revision as of 10:44, 4 May 2008

Image:2psp.jpg

Template:STRUCTURE 2psp

PORCINE PANCREATIC SPASMOLYTIC POLYPEPTIDE


Overview

The structure of a trigonal crystal form of porcine pancreatic spasmolytic polypeptide (PSP) has been solved by molecular replacement and refined to 1.95 A resolution. Three heavy-atom derivatives were prepared, giving unbiased phase information, which was used in the model building of the protein molecules. The final conventional R value is 19.8% with the inclusion of 183 water molecules. PSP crystallizes as a dimer in space group P3(1)21 with a non-crystallographic twofold axis relating the monomers. The monomer consists of two very similar domains each composed of three loop regions. Two clefts are found in the monomer, one in each domain, that are proposed as possible substrate-binding sites. Important interactions have been identified in the proposed substrate-binding sites, where conserved water molecules probably mimic the hydrophilic positions of the substrate. The estimated cleft size is 9 x 9 x 12 A. Analysis of the charge distribution within the clefts, by an electrostatic potential calculation, shows the clefts to be essentially non-charged.

About this Structure

2PSP is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of porcine pancreatic spasmolytic polypeptide at 1.95 A resolution., Petersen TN, Henriksen A, Gajhede M, Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):730-7. PMID:15299636 Page seeded by OCA on Sun May 4 13:44:14 2008

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