2pxc

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[[Image:2pxc.jpg|left|200px]]
[[Image:2pxc.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2pxc |SIZE=350|CAPTION= <scene name='initialview01'>2pxc</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2pxc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=G3A:GUANOSINE-P3-ADENOSINE-5&#39;,5&#39;-TRIPHOSPHATE'>G3A</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= NS5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11079 Murray Valley encephalitis virus])
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-->
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|DOMAIN=
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{{STRUCTURE_2pxc| PDB=2pxc | SCENE= }}
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|RELATEDENTRY=[[2px2|2PX2]], [[2px4|2PX4]], [[2px5|2PX5]], [[2px8|2PX8]], [[2pxa|2PXA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxc OCA], [http://www.ebi.ac.uk/pdbsum/2pxc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pxc RCSB]</span>
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}}
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'''Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAM and GTPA'''
'''Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAM and GTPA'''
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[[Category: Verma, A.]]
[[Category: Verma, A.]]
[[Category: Walter, T S.]]
[[Category: Walter, T S.]]
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[[Category: g3a]]
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[[Category: G3a]]
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[[Category: gtpa]]
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[[Category: Gtpa]]
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[[Category: methyltransferase]]
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[[Category: Methyltransferase]]
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[[Category: murray valley encephalitis virus]]
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[[Category: Murray valley encephalitis virus]]
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[[Category: oppf]]
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[[Category: Oppf]]
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[[Category: oxford protein production facility]]
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[[Category: Oxford protein production facility]]
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[[Category: sam]]
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[[Category: Sam]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:58:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:41:59 2008''
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Revision as of 10:58, 4 May 2008

Image:2pxc.jpg

Template:STRUCTURE 2pxc

Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAM and GTPA


Overview

We have determined the high resolution crystal structure of the methyltransferase domain of the NS5 polypeptide from the Murray Valley encephalitis virus. This domain is unusual in having both the N7 and 2'-O methyltransferase activity required for Cap 1 synthesis. We have also determined structures for complexes of this domain with nucleotides and cap analogues providing information on cap binding, based on which we suggest a model of how the sequential methylation of the N7 and 2'-O groups of the cap may be coordinated.

About this Structure

2PXC is a Single protein structure of sequence from Murray valley encephalitis virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues., Assenberg R, Ren J, Verma A, Walter TS, Alderton D, Hurrelbrink RJ, Fuller SD, Bressanelli S, Owens RJ, Stuart DI, Grimes JM, J Gen Virol. 2007 Aug;88(Pt 8):2228-36. PMID:17622627 Page seeded by OCA on Sun May 4 13:58:01 2008

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OCA

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