2q86

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(New page: 200px {{Structure |PDB= 2q86 |SIZE=350|CAPTION= <scene name='initialview01'>2q86</scene>, resolution 1.85&Aring; |SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+...)
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[[Image:2q86.jpg|left|200px]]
[[Image:2q86.jpg|left|200px]]
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{{Structure
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|PDB= 2q86 |SIZE=350|CAPTION= <scene name='initialview01'>2q86</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_2q86", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+500'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+501'>AC2</scene>, <scene name='pdbsite=AC3:Bma+Binding+Site+For+Residue+A+502'>AC3</scene>, <scene name='pdbsite=AC4:Man+Binding+Site+For+Residue+A+503'>AC4</scene>, <scene name='pdbsite=AC5:Fuc+Binding+Site+For+Residue+A+504'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+B+510'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Residue+C+500'>AC7</scene>, <scene name='pdbsite=AC8:Nag+Binding+Site+For+Residue+C+501'>AC8</scene> and <scene name='pdbsite=AC9:Fuc+Binding+Site+For+Residue+C+506'>AC9</scene>
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= Valpha14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Vbeta8.2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam09291 DUF1968], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00099 IGv], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam07686 V-set], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00098 IGc]</span>
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{{STRUCTURE_2q86| PDB=2q86 | SCENE= }}
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|RELATEDENTRY=[[2eyr|2EYR]], [[2cde|2CDE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q86 OCA], [http://www.ebi.ac.uk/pdbsum/2q86 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2q86 RCSB]</span>
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}}
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'''Structure of the mouse invariant NKT cell receptor Valpha14'''
'''Structure of the mouse invariant NKT cell receptor Valpha14'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Zajonc, D M.]]
[[Category: Zajonc, D M.]]
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[[Category: glycolipid recognition]]
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[[Category: Glycolipid recognition]]
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[[Category: immune system]]
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[[Category: Immune system]]
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[[Category: inkt cell]]
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[[Category: Inkt cell]]
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[[Category: innate immunity]]
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[[Category: Innate immunity]]
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[[Category: tcr]]
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[[Category: Tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:30:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:58:11 2008''
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Revision as of 11:30, 4 May 2008

Image:2q86.jpg

Template:STRUCTURE 2q86

Structure of the mouse invariant NKT cell receptor Valpha14


Overview

The semi-invariant Valpha14Jalpha18 T cell receptor (TCR) is expressed by regulatory NKT cells and has the unique ability to recognize chemically diverse ligands presented by CD1d. The crystal structure of CD1d complexed to a natural, endogenous ligand, isoglobotrihexosylceramide (iGb3), illustrates the extent of this diversity when compared to the binding of potent, exogenous ligands, such as alpha-galactosylceramide (alpha-GalCer). A single mode of recognition for these two classes of ligands would then appear problematic for a single T cell receptor. However, the Valpha14 TCR adopts two different conformations in the crystal where, in one configuration, the presence of a larger cavity between the two CDR3 regions could accommodate iGb3 and, in the other, a smaller cavity fits alpha-GalCer more snugly. Alternatively, the extended iGb3 headgroup could be "squashed" upon docking of the TCR and accommodated between the CD1 and TCR surfaces. Thus, the same TCR may adopt alternative modes of recognition for these foreign and self-ligands for NKT cell activation.

About this Structure

2Q86 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids., Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L, J Mol Biol. 2008 Apr 4;377(4):1104-16. Epub 2008 Jan 31. PMID:18295796 Page seeded by OCA on Sun May 4 14:30:54 2008

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