2q8k

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[[Image:2q8k.jpg|left|200px]]
[[Image:2q8k.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2q8k |SIZE=350|CAPTION= <scene name='initialview01'>2q8k</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2q8k", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= PA2G4, EBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2q8k| PDB=2q8k | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8k OCA], [http://www.ebi.ac.uk/pdbsum/2q8k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2q8k RCSB]</span>
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}}
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'''The crystal structure of Ebp1'''
'''The crystal structure of Ebp1'''
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[[Category: Sinning, I.]]
[[Category: Sinning, I.]]
[[Category: Wild, K.]]
[[Category: Wild, K.]]
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[[Category: ebp1]]
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[[Category: Ebp1]]
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[[Category: methionine aminopeptidase]]
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[[Category: Methionine aminopeptidase]]
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[[Category: pa2g4]]
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[[Category: Pa2g4]]
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[[Category: pita-bread]]
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[[Category: Pita-bread]]
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[[Category: transcription]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:32:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:46:14 2008''
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Revision as of 11:32, 4 May 2008

Image:2q8k.jpg

Template:STRUCTURE 2q8k

The crystal structure of Ebp1


Overview

The ErbB-3 receptor binding protein (Ebp1) is a member of the proliferation-associated 2G4 (PA2G4) family implicated in regulation of cell growth and differentiation. Here, we report the crystal structure of the human Ebp1 at 1.6 A resolution. The protein has the conserved pita bread fold of methionine aminopeptidases, but without the characteristic enzymatic activity. Moreover, Ebp1 is known to interact with a number of proteins and RNAs involved in either transcription regulation or translation control. The structure provides insights in how Ebp1 discriminates between its different interaction partners.

About this Structure

2Q8K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions., Kowalinski E, Bange G, Bradatsch B, Hurt E, Wild K, Sinning I, FEBS Lett. 2007 Sep 18;581(23):4450-4. Epub 2007 Aug 27. PMID:17765895 Page seeded by OCA on Sun May 4 14:32:11 2008

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