2qa4

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(New page: 200px {{Structure |PDB= 2qa4 |SIZE=350|CAPTION= <scene name='initialview01'>2qa4</scene>, resolution 3.0&Aring; |SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+Fo...)
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[[Image:2qa4.jpg|left|200px]]
[[Image:2qa4.jpg|left|200px]]
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{{Structure
+
<!--
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|PDB= 2qa4 |SIZE=350|CAPTION= <scene name='initialview01'>2qa4</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_2qa4", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+0+1'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+0+2924'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+0+2925'>AC3</scene>, <scene name='pdbsite=AC4:Mg+Binding+Site+For+Residue+0+2926'>AC4</scene>, <scene name='pdbsite=AC5:Mg+Binding+Site+For+Residue+0+2927'>AC5</scene>, <scene name='pdbsite=AC6:Mg+Binding+Site+For+Residue+0+2928'>AC6</scene>, <scene name='pdbsite=AC7:Mg+Binding+Site+For+Residue+0+2929'>AC7</scene>, <scene name='pdbsite=AC8:Mg+Binding+Site+For+Residue+0+2930'>AC8</scene>, <scene name='pdbsite=AC9:Mg+Binding+Site+For+Residue+0+2931'>AC9</scene>, <scene name='pdbsite=BC1:Mg+Binding+Site+For+Residue+0+2932'>BC1</scene>, <scene name='pdbsite=BC2:Mg+Binding+Site+For+Residue+0+2933'>BC2</scene>, <scene name='pdbsite=BC3:Mg+Binding+Site+For+Residue+0+2934'>BC3</scene>, <scene name='pdbsite=BC4:Mg+Binding+Site+For+Residue+0+2935'>BC4</scene>, <scene name='pdbsite=BC5:Mg+Binding+Site+For+Residue+0+2936'>BC5</scene>, <scene name='pdbsite=BC6:Mg+Binding+Site+For+Residue+0+2937'>BC6</scene>, <scene name='pdbsite=BC7:Mg+Binding+Site+For+Residue+0+2938'>BC7</scene>, <scene name='pdbsite=BC8:Mg+Binding+Site+For+Residue+0+2939'>BC8</scene>, <scene name='pdbsite=BC9:Mg+Binding+Site+For+Residue+0+2940'>BC9</scene>, <scene name='pdbsite=CC1:Mg+Binding+Site+For+Residue+0+2941'>CC1</scene>, <scene name='pdbsite=CC2:Mg+Binding+Site+For+Residue+0+2942'>CC2</scene>, <scene name='pdbsite=CC3:Mg+Binding+Site+For+Residue+0+2944'>CC3</scene>, <scene name='pdbsite=CC4:Mg+Binding+Site+For+Residue+0+2945'>CC4</scene>, <scene name='pdbsite=CC5:Mg+Binding+Site+For+Residue+0+2946'>CC5</scene>, <scene name='pdbsite=CC6:Mg+Binding+Site+For+Residue+0+2947'>CC6</scene>, <scene name='pdbsite=CC7:Mg+Binding+Site+For+Residue+0+2948'>CC7</scene>, <scene name='pdbsite=CC8:Mg+Binding+Site+For+Residue+0+2949'>CC8</scene>, <scene name='pdbsite=CC9:Mg+Binding+Site+For+Residue+0+2950'>CC9</scene>, <scene name='pdbsite=DC1:Mg+Binding+Site+For+Residue+0+2951'>DC1</scene>, <scene name='pdbsite=DC2:Mg+Binding+Site+For+Residue+0+2952'>DC2</scene>, <scene name='pdbsite=DC3:Mg+Binding+Site+For+Residue+0+2953'>DC3</scene>, <scene name='pdbsite=DC4:Mg+Binding+Site+For+Residue+0+2954'>DC4</scene>, <scene name='pdbsite=DC5:Mg+Binding+Site+For+Residue+0+2955'>DC5</scene>, <scene name='pdbsite=DC6:Mg+Binding+Site+For+Residue+0+2956'>DC6</scene>, <scene name='pdbsite=DC7:Mg+Binding+Site+For+Residue+0+2957'>DC7</scene>, <scene name='pdbsite=DC8:Mg+Binding+Site+For+Residue+0+2963'>DC8</scene>, <scene name='pdbsite=DC9:Mg+Binding+Site+For+Residue+0+2964'>DC9</scene>, <scene name='pdbsite=EC1:Mg+Binding+Site+For+Residue+0+2965'>EC1</scene>, <scene name='pdbsite=EC2:Mg+Binding+Site+For+Residue+0+2966'>EC2</scene>, <scene name='pdbsite=EC3:Mg+Binding+Site+For+Residue+0+2968'>EC3</scene>, <scene name='pdbsite=EC4:Mg+Binding+Site+For+Residue+0+2969'>EC4</scene>, <scene name='pdbsite=EC5:Mg+Binding+Site+For+Residue+0+2970'>EC5</scene>, <scene name='pdbsite=EC6:Mg+Binding+Site+For+Residue+0+2971'>EC6</scene>, <scene name='pdbsite=EC7:Mg+Binding+Site+For+Residue+0+2972'>EC7</scene>, <scene name='pdbsite=EC8:Mg+Binding+Site+For+Residue+0+2973'>EC8</scene>, <scene name='pdbsite=EC9:Mg+Binding+Site+For+Residue+0+2974'>EC9</scene>, <scene name='pdbsite=FC1:Mg+Binding+Site+For+Residue+0+2975'>FC1</scene>, <scene name='pdbsite=FC2:Mg+Binding+Site+For+Residue+0+2976'>FC2</scene>, <scene name='pdbsite=FC3:Mg+Binding+Site+For+Residue+B+338'>FC3</scene>, <scene name='pdbsite=FC4:Mg+Binding+Site+For+Residue+0+2977'>FC4</scene>, <scene name='pdbsite=FC5:Mg+Binding+Site+For+Residue+0+2978'>FC5</scene>, <scene name='pdbsite=FC6:Mg+Binding+Site+For+Residue+0+2979'>FC6</scene>, <scene name='pdbsite=FC7:Mg+Binding+Site+For+Residue+0+2980'>FC7</scene>, <scene name='pdbsite=FC8:Mg+Binding+Site+For+Residue+0+2981'>FC8</scene>, <scene name='pdbsite=FC9:Mg+Binding+Site+For+Residue+0+2982'>FC9</scene>, <scene name='pdbsite=GC1:Mg+Binding+Site+For+Residue+0+2983'>GC1</scene>, <scene name='pdbsite=GC2:Mg+Binding+Site+For+Residue+0+2984'>GC2</scene>, <scene name='pdbsite=GC3:Mg+Binding+Site+For+Residue+0+2985'>GC3</scene>, <scene name='pdbsite=GC4:Mg+Binding+Site+For+Residue+A+240'>GC4</scene>, <scene name='pdbsite=GC5:Mg+Binding+Site+For+Residue+A+241'>GC5</scene>, <scene name='pdbsite=GC6:Mg+Binding+Site+For+Residue+0+2986'>GC6</scene>, <scene name='pdbsite=GC7:Mg+Binding+Site+For+Residue+0+2987'>GC7</scene>, <scene name='pdbsite=GC8:Mg+Binding+Site+For+Residue+K+133'>GC8</scene>, <scene name='pdbsite=GC9:Mg+Binding+Site+For+Residue+0+2988'>GC9</scene>, <scene name='pdbsite=HC1:Mg+Binding+Site+For+Residue+0+2990'>HC1</scene>, <scene name='pdbsite=HC2:Mg+Binding+Site+For+Residue+T+120'>HC2</scene>, <scene name='pdbsite=HC3:Mg+Binding+Site+For+Residue+0+2991'>HC3</scene>, <scene name='pdbsite=HC4:Mg+Binding+Site+For+Residue+0+2992'>HC4</scene>, <scene name='pdbsite=HC5:Mg+Binding+Site+For+Residue+0+2994'>HC5</scene>, <scene name='pdbsite=HC6:Mg+Binding+Site+For+Residue+3+93'>HC6</scene>, <scene name='pdbsite=HC7:Mg+Binding+Site+For+Residue+0+2995'>HC7</scene>, <scene name='pdbsite=HC8:Mg+Binding+Site+For+Residue+0+2996'>HC8</scene>, <scene name='pdbsite=HC9:Mg+Binding+Site+For+Residue+0+2997'>HC9</scene>, <scene name='pdbsite=IC1:Mg+Binding+Site+For+Residue+0+3000'>IC1</scene>, <scene name='pdbsite=IC2:Mg+Binding+Site+For+Residue+0+3001'>IC2</scene>, <scene name='pdbsite=IC3:Mg+Binding+Site+For+Residue+0+3002'>IC3</scene>, <scene name='pdbsite=IC4:Mg+Binding+Site+For+Residue+0+3003'>IC4</scene>, <scene name='pdbsite=IC5:Mg+Binding+Site+For+Residue+0+3004'>IC5</scene>, <scene name='pdbsite=IC6:Mg+Binding+Site+For+Residue+0+3005'>IC6</scene>, <scene name='pdbsite=IC7:Mg+Binding+Site+For+Residue+0+3008'>IC7</scene>, <scene name='pdbsite=IC8:Mg+Binding+Site+For+Residue+0+3009'>IC8</scene>, <scene name='pdbsite=IC9:Mg+Binding+Site+For+Residue+0+3010'>IC9</scene>, <scene name='pdbsite=JC1:Mg+Binding+Site+For+Residue+9+123'>JC1</scene>, <scene name='pdbsite=JC2:Mg+Binding+Site+For+Residue+0+3011'>JC2</scene>, <scene name='pdbsite=JC3:Mg+Binding+Site+For+Residue+0+3012'>JC3</scene>, <scene name='pdbsite=JC4:Mg+Binding+Site+For+Residue+0+3014'>JC4</scene>, <scene name='pdbsite=JC5:Mg+Binding+Site+For+Residue+0+3016'>JC5</scene>, <scene name='pdbsite=JC6:Mg+Binding+Site+For+Residue+0+3017'>JC6</scene>, <scene name='pdbsite=JC7:Mg+Binding+Site+For+Residue+0+3018'>JC7</scene>, <scene name='pdbsite=JC8:Mg+Binding+Site+For+Residue+0+3019'>JC8</scene>, <scene name='pdbsite=JC9:Mg+Binding+Site+For+Residue+0+3020'>JC9</scene>, <scene name='pdbsite=KC1:Mg+Binding+Site+For+Residue+0+3021'>KC1</scene>, <scene name='pdbsite=KC2:Mg+Binding+Site+For+Residue+Y+241'>KC2</scene>, <scene name='pdbsite=KC3:Mg+Binding+Site+For+Residue+0+3023'>KC3</scene>, <scene name='pdbsite=KC4:Mg+Binding+Site+For+Residue+0+3024'>KC4</scene>, <scene name='pdbsite=KC5:Mg+Binding+Site+For+Residue+0+3025'>KC5</scene>, <scene name='pdbsite=KC6:Mg+Binding+Site+For+Residue+0+3027'>KC6</scene>, <scene name='pdbsite=KC7:Mg+Binding+Site+For+Residue+0+3029'>KC7</scene>, <scene name='pdbsite=KC8:Mg+Binding+Site+For+Residue+0+3030'>KC8</scene>, <scene name='pdbsite=KC9:K+Binding+Site+For+Residue+0+3031'>KC9</scene>, <scene name='pdbsite=LC1:K+Binding+Site+For+Residue+M+196'>LC1</scene>, <scene name='pdbsite=LC2:Na+Binding+Site+For+Residue+0+3032'>LC2</scene>, <scene name='pdbsite=LC3:Na+Binding+Site+For+Residue+0+3033'>LC3</scene>, <scene name='pdbsite=LC4:Na+Binding+Site+For+Residue+0+3034'>LC4</scene>, <scene name='pdbsite=LC5:Na+Binding+Site+For+Residue+C+247'>LC5</scene>, <scene name='pdbsite=LC6:Na+Binding+Site+For+Residue+0+3035'>LC6</scene>, <scene name='pdbsite=LC7:Na+Binding+Site+For+Residue+0+3036'>LC7</scene>, <scene name='pdbsite=LC8:Na+Binding+Site+For+Residue+0+3037'>LC8</scene>, <scene name='pdbsite=LC9:Na+Binding+Site+For+Residue+0+3038'>LC9</scene>, <scene name='pdbsite=MC1:Na+Binding+Site+For+Residue+H+172'>MC1</scene>, <scene name='pdbsite=MC2:Na+Binding+Site+For+Residue+0+3039'>MC2</scene>, <scene name='pdbsite=MC3:Na+Binding+Site+For+Residue+0+3040'>MC3</scene>, <scene name='pdbsite=MC4:Na+Binding+Site+For+Residue+S+85'>MC4</scene>, <scene name='pdbsite=MC5:Na+Binding+Site+For+Residue+0+3041'>MC5</scene>, <scene name='pdbsite=MC6:Na+Binding+Site+For+Residue+0+3042'>MC6</scene>, <scene name='pdbsite=MC7:Na+Binding+Site+For+Residue+0+3043'>MC7</scene>, <scene name='pdbsite=MC8:Na+Binding+Site+For+Residue+0+3044'>MC8</scene>, <scene name='pdbsite=MC9:Na+Binding+Site+For+Residue+0+3045'>MC9</scene>, <scene name='pdbsite=NC1:Na+Binding+Site+For+Residue+0+3046'>NC1</scene>, <scene name='pdbsite=NC2:Na+Binding+Site+For+Residue+0+3047'>NC2</scene>, <scene name='pdbsite=NC3:Na+Binding+Site+For+Residue+0+3048'>NC3</scene>, <scene name='pdbsite=NC4:Na+Binding+Site+For+Residue+0+3049'>NC4</scene>, <scene name='pdbsite=NC5:Na+Binding+Site+For+Residue+0+3051'>NC5</scene>, <scene name='pdbsite=NC6:Na+Binding+Site+For+Residue+0+3052'>NC6</scene>, <scene name='pdbsite=NC7:Na+Binding+Site+For+Residue+0+3053'>NC7</scene>, <scene name='pdbsite=NC8:Na+Binding+Site+For+Residue+0+3054'>NC8</scene>, <scene name='pdbsite=NC9:Na+Binding+Site+For+Residue+0+3055'>NC9</scene>, <scene name='pdbsite=OC1:Na+Binding+Site+For+Residue+0+3056'>OC1</scene>, <scene name='pdbsite=OC2:Na+Binding+Site+For+Residue+0+3057'>OC2</scene>, <scene name='pdbsite=OC3:Na+Binding+Site+For+Residue+0+3058'>OC3</scene>, <scene name='pdbsite=OC4:Na+Binding+Site+For+Residue+0+3059'>OC4</scene>, <scene name='pdbsite=OC5:Na+Binding+Site+For+Residue+0+3060'>OC5</scene>, <scene name='pdbsite=OC6:Na+Binding+Site+For+Residue+0+3061'>OC6</scene>, <scene name='pdbsite=OC7:Na+Binding+Site+For+Residue+0+3062'>OC7</scene>, <scene name='pdbsite=OC8:Na+Binding+Site+For+Residue+0+3063'>OC8</scene>, <scene name='pdbsite=OC9:Na+Binding+Site+For+Residue+0+3064'>OC9</scene>, <scene name='pdbsite=PC1:Na+Binding+Site+For+Residue+0+3065'>PC1</scene>, <scene name='pdbsite=PC2:Na+Binding+Site+For+Residue+R+155'>PC2</scene>, <scene name='pdbsite=PC3:Na+Binding+Site+For+Residue+0+3066'>PC3</scene>, <scene name='pdbsite=PC4:Na+Binding+Site+For+Residue+0+3067'>PC4</scene>, <scene name='pdbsite=PC5:Na+Binding+Site+For+Residue+0+3068'>PC5</scene>, <scene name='pdbsite=PC6:Na+Binding+Site+For+Residue+0+3069'>PC6</scene>, <scene name='pdbsite=PC7:Na+Binding+Site+For+Residue+0+3070'>PC7</scene>, <scene name='pdbsite=PC8:Na+Binding+Site+For+Residue+0+3071'>PC8</scene>, <scene name='pdbsite=PC9:Na+Binding+Site+For+Residue+A+242'>PC9</scene>, <scene name='pdbsite=QC1:Na+Binding+Site+For+Residue+J+146'>QC1</scene>, <scene name='pdbsite=QC2:Na+Binding+Site+For+Residue+M+197'>QC2</scene>, <scene name='pdbsite=QC3:Na+Binding+Site+For+Residue+Q+96'>QC3</scene>, <scene name='pdbsite=QC4:Na+Binding+Site+For+Residue+0+3072'>QC4</scene>, <scene name='pdbsite=QC5:Na+Binding+Site+For+Residue+0+3073'>QC5</scene>, <scene name='pdbsite=QC6:Na+Binding+Site+For+Residue+9+125'>QC6</scene>, <scene name='pdbsite=QC7:Na+Binding+Site+For+Residue+0+3074'>QC7</scene>, <scene name='pdbsite=QC8:Na+Binding+Site+For+Residue+0+3075'>QC8</scene>, <scene name='pdbsite=QC9:Na+Binding+Site+For+Residue+0+3076'>QC9</scene>, <scene name='pdbsite=RC1:Na+Binding+Site+For+Residue+0+3077'>RC1</scene>, <scene name='pdbsite=RC2:Na+Binding+Site+For+Residue+0+3078'>RC2</scene>, <scene name='pdbsite=RC3:Na+Binding+Site+For+Residue+0+3079'>RC3</scene>, <scene name='pdbsite=RC4:Na+Binding+Site+For+Residue+0+3080'>RC4</scene>, <scene name='pdbsite=RC5:Na+Binding+Site+For+Residue+0+3081'>RC5</scene>, <scene name='pdbsite=RC6:Na+Binding+Site+For+Residue+0+3082'>RC6</scene>, <scene name='pdbsite=RC7:Na+Binding+Site+For+Residue+0+3083'>RC7</scene>, <scene name='pdbsite=RC8:Na+Binding+Site+For+Residue+0+3084'>RC8</scene>, <scene name='pdbsite=RC9:Na+Binding+Site+For+Residue+0+3086'>RC9</scene>, <scene name='pdbsite=SC1:Na+Binding+Site+For+Residue+0+3087'>SC1</scene>, <scene name='pdbsite=SC2:Na+Binding+Site+For+Residue+0+3088'>SC2</scene>, <scene name='pdbsite=SC3:Na+Binding+Site+For+Residue+0+3089'>SC3</scene>, <scene name='pdbsite=SC4:Na+Binding+Site+For+Residue+0+3090'>SC4</scene>, <scene name='pdbsite=SC5:Na+Binding+Site+For+Residue+0+3093'>SC5</scene>, <scene name='pdbsite=SC6:Na+Binding+Site+For+Residue+0+3094'>SC6</scene>, <scene name='pdbsite=SC7:Na+Binding+Site+For+Residue+0+3095'>SC7</scene>, <scene name='pdbsite=SC8:Na+Binding+Site+For+Residue+0+3096'>SC8</scene>, <scene name='pdbsite=SC9:Na+Binding+Site+For+Residue+0+3097'>SC9</scene>, <scene name='pdbsite=TC1:Na+Binding+Site+For+Residue+0+3098'>TC1</scene>, <scene name='pdbsite=TC2:Na+Binding+Site+For+Residue+0+3099'>TC2</scene>, <scene name='pdbsite=TC3:Na+Binding+Site+For+Residue+0+3100'>TC3</scene>, <scene name='pdbsite=TC4:Na+Binding+Site+For+Residue+L+165'>TC4</scene>, <scene name='pdbsite=TC5:Na+Binding+Site+For+Residue+0+3101'>TC5</scene>, <scene name='pdbsite=TC6:Na+Binding+Site+For+Residue+0+3102'>TC6</scene>, <scene name='pdbsite=TC7:Na+Binding+Site+For+Residue+9+126'>TC7</scene>, <scene name='pdbsite=TC8:Na+Binding+Site+For+Residue+0+3104'>TC8</scene>, <scene name='pdbsite=TC9:Na+Binding+Site+For+Residue+R+156'>TC9</scene>, <scene name='pdbsite=UC1:Cd+Binding+Site+For+Residue+U+67'>UC1</scene>, <scene name='pdbsite=UC2:Cd+Binding+Site+For+Residue+1+57'>UC2</scene>, <scene name='pdbsite=UC3:Cd+Binding+Site+For+Residue+Z+93'>UC3</scene>, <scene name='pdbsite=UC4:Cl+Binding+Site+For+Residue+J+147'>UC4</scene>, <scene name='pdbsite=UC5:Cl+Binding+Site+For+Residue+J+148'>UC5</scene>, <scene name='pdbsite=UC6:Cl+Binding+Site+For+Residue+0+3105'>UC6</scene>, <scene name='pdbsite=UC7:Cl+Binding+Site+For+Residue+3+95'>UC7</scene>, <scene name='pdbsite=UC8:Cl+Binding+Site+For+Residue+0+3106'>UC8</scene>, <scene name='pdbsite=UC9:Cl+Binding+Site+For+Residue+N+187'>UC9</scene>, <scene name='pdbsite=VC1:Cl+Binding+Site+For+Residue+Q+97'>VC1</scene>, <scene name='pdbsite=VC2:Cl+Binding+Site+For+Residue+K+134'>VC2</scene>, <scene name='pdbsite=VC3:Cl+Binding+Site+For+Residue+0+3107'>VC3</scene>, <scene name='pdbsite=VC4:Cl+Binding+Site+For+Residue+0+3108'>VC4</scene>, <scene name='pdbsite=VC5:Cl+Binding+Site+For+Residue+0+3109'>VC5</scene>, <scene name='pdbsite=VC6:Cl+Binding+Site+For+Residue+0+3110'>VC6</scene>, <scene name='pdbsite=VC7:Cl+Binding+Site+For+Residue+0+3111'>VC7</scene>, <scene name='pdbsite=VC8:Cl+Binding+Site+For+Residue+M+198'>VC8</scene>, <scene name='pdbsite=VC9:Cl+Binding+Site+For+Residue+B+339'>VC9</scene>, <scene name='pdbsite=WC1:Cl+Binding+Site+For+Residue+Y+242'>WC1</scene>, <scene name='pdbsite=WC2:Cl+Binding+Site+For+Residue+J+149'>WC2</scene> and <scene name='pdbsite=WC3:Cl+Binding+Site+For+Residue+0+3112'>WC3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMG:O2&#39;-METHYLGUANOSINE-5&#39;-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2&#39;-METHYLURIDINE+5&#39;-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5&#39;-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5&#39;-MONOPHOSHATE'>UR3</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
+
-->
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK01143 rpl11p], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00349 Ribosomal_L11], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0089 RplW], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK05518 rpl6p], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00347 Ribosomal_L6], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK01192 PRK01192], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1727 RPL18A], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04005 PRK04005], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK01191 rpl24p], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01418 Ribosomal_L19e_A], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK01242 rpl39e], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01246 Ribosomal_L24e], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK08571 rpl14p], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK08569 rpl18p], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04179 rpl37e], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00673 Ribosomal_L5_C], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04219 rpl5p], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00281 Ribosomal_L5], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK12766 PRK12766], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01657 Ribosomal_L7], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK03976 rpl37ae], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00181 Ribosomal_L2], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK09612 rpl2p], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam03947 Ribosomal_L2_C], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0244 RplJ], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00392 Ribosomal_L13], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK06419 rpl15p], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04243 PRK04243], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00336 Ribosomal_L22], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04175 rpl7ae], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04231 rpl3p], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00831 Ribosomal_L29], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04199 rpl10e], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04306 PRK04306], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK05767 rpl44e], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04042 rpl4lp]</span>
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{{STRUCTURE_2qa4| PDB=2qa4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qa4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qa4 OCA], [http://www.ebi.ac.uk/pdbsum/2qa4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qa4 RCSB]</span>
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}}
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'''A more complete structure of the the L7/L12 stalk of the Haloarcula marismortui 50S large ribosomal subunit'''
'''A more complete structure of the the L7/L12 stalk of the Haloarcula marismortui 50S large ribosomal subunit'''
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[[Category: Kavran, J M.]]
[[Category: Kavran, J M.]]
[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
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[[Category: large ribosomal subunit]]
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[[Category: Large ribosomal subunit]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: ribonucleoprotein]]
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[[Category: Ribonucleoprotein]]
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[[Category: ribosomal protein]]
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[[Category: Ribosomal protein]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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[[Category: rna-binding]]
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[[Category: Rna-binding]]
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[[Category: rrna-binding]]
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[[Category: Rrna-binding]]
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[[Category: trna-binding]]
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[[Category: Trna-binding]]
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[[Category: zinc]]
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[[Category: Zinc]]
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[[Category: zinc-finger]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:36:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:58:10 2008''
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Revision as of 11:36, 4 May 2008

Image:2qa4.jpg

Template:STRUCTURE 2qa4

A more complete structure of the the L7/L12 stalk of the Haloarcula marismortui 50S large ribosomal subunit


Overview

Initiation factors, elongation factors, and release factors all interact with the L7/L12 stalk of the large ribosomal subunit during their respective GTP-dependent cycles on the ribosome. Electron density corresponding to the stalk is not present in previous crystal structures of either 50 S subunits or 70 S ribosomes. We have now discovered conditions that result in a more ordered factor-binding center in the Haloarcula marismortui (H.ma) large ribosomal subunit crystals and consequently allows the visualization of the full-length L11, the N-terminal domain (NTD) of L10 and helices 43 and 44 of 23 S rRNA. The resulting model is currently the most complete reported structure of a L7/L12 stalk in the context of a ribosome. This region contains a series of intermolecular interfaces that are smaller than those typically seen in other ribonucleoprotein interactions within the 50 S subunit. Comparisons of the L11 NTD position between the current structure, which is has an NTD splayed out with respect to previous structures, and other structures of ribosomes in different functional states demonstrates a dynamic range of L11 NTD movements. We propose that the L11 NTD moves through three different relative positions during the translational cycle: apo-ribosome, factor-bound pre-GTP hydrolysis and post-GTP hydrolysis. These positions outline a pathway for L11 NTD movements that are dependent on the specific nucleotide state of the bound ligand. These three states are represented by the orientations of the L11 NTD relative to the ribosome and suggest that L11 may play a more specialized role in the factor binding cycle than previously appreciated.

About this Structure

2QA4 is a Protein complex structure of sequences from Haloarcula marismortui. Full crystallographic information is available from OCA.

Reference

Structure of the base of the L7/L12 stalk of the Haloarcula marismortui large ribosomal subunit: analysis of L11 movements., Kavran JM, Steitz TA, J Mol Biol. 2007 Aug 24;371(4):1047-59. Epub 2007 Jun 4. PMID:17599351 Page seeded by OCA on Sun May 4 14:36:49 2008

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