1z3g

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(New page: 200px<br /> <applet load="1z3g" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z3g, resolution 3.3&Aring;" /> '''Crystal structure of...)
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Revision as of 07:38, 18 November 2007

Image:1z3g.gif

1z3g, resolution 3.3Å

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Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8

Overview

P25 and P28 proteins are essential for Plasmodium parasites to infect, mosquitoes and are leading candidates for a transmission-blocking malaria, vaccine. The Plasmodium vivax P25 is a triangular prism that could tile, the parasite surface. The residues forming the triangle are conserved in, P25 and P28 from all Plasmodium species. A cocrystal structure shows that, a transmission-blocking antibody uses only its heavy chain to bind Pvs25, at a vertex of the triangle.

About this Structure

1Z3G is a Single protein structure of sequence from Mus musculus and Plasmodium vivax. Full crystallographic information is available from OCA.

Reference

The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807

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