2qfa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2qfa.jpg|left|200px]]
[[Image:2qfa.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2qfa |SIZE=350|CAPTION= <scene name='initialview01'>2qfa</scene>, resolution 1.400&Aring;
+
The line below this paragraph, containing "STRUCTURE_2qfa", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= BIRC5, API4, IAP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CDCA8, PESCRG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), INCENP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2qfa| PDB=2qfa | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfa OCA], [http://www.ebi.ac.uk/pdbsum/2qfa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qfa RCSB]</span>
+
-
}}
+
'''Crystal structure of a Survivin-Borealin-INCENP core complex'''
'''Crystal structure of a Survivin-Borealin-INCENP core complex'''
Line 31: Line 28:
[[Category: Lindner, D.]]
[[Category: Lindner, D.]]
[[Category: Nigg, E A.]]
[[Category: Nigg, E A.]]
-
[[Category: alternative splicing]]
+
[[Category: Alternative splicing]]
-
[[Category: apoptosis]]
+
[[Category: Apoptosis]]
-
[[Category: cell cycle]]
+
[[Category: Cell cycle]]
-
[[Category: cell cycle/cell cycle/cell cycle complex]]
+
[[Category: Cell cycle/cell cycle/cell cycle complex]]
-
[[Category: cell division]]
+
[[Category: Cell division]]
-
[[Category: centromere]]
+
[[Category: Centromere]]
-
[[Category: chromosomal protein]]
+
[[Category: Chromosomal protein]]
-
[[Category: coiled coil]]
+
[[Category: Coiled coil]]
-
[[Category: cytoplasm]]
+
[[Category: Cytoplasm]]
-
[[Category: long helix]]
+
[[Category: Long helix]]
-
[[Category: metal-binding]]
+
[[Category: Metal-binding]]
-
[[Category: microtubule]]
+
[[Category: Microtubule]]
-
[[Category: mitosis]]
+
[[Category: Mitosis]]
-
[[Category: nucleus]]
+
[[Category: Nucleus]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: protease inhibitor]]
+
[[Category: Protease inhibitor]]
-
[[Category: protein complex]]
+
[[Category: Protein complex]]
-
[[Category: thiol protease inhibitor]]
+
[[Category: Thiol protease inhibitor]]
-
[[Category: three-helical-bundle]]
+
[[Category: Three-helical-bundle]]
-
[[Category: zinc]]
+
[[Category: Zinc]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:51:27 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:48:39 2008''
+

Revision as of 11:51, 4 May 2008

Image:2qfa.jpg

Template:STRUCTURE 2qfa

Crystal structure of a Survivin-Borealin-INCENP core complex


Overview

The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis. CPC functions are connected to its localization. The complex first localizes to centromeres and later associates with the central spindle and midbody. Survivin, Borealin, and INCENP are the three components of the CPC that regulate the activity and localization of its enzymatic component, the kinase Aurora B. We determined the 1.4 A resolution crystal structure of the regulatory core of the CPC, revealing that Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. We used siRNA rescue experiments with structure-based mutants to explore the requirements for CPC localization. We show that the intertwined structural interactions of the core components lead to functional interdependence. Association of the core "passenger" proteins creates a single structural unit, whose composite molecular surface presents conserved residues essential for central spindle and midbody localization.

About this Structure

2QFA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together., Jeyaprakash AA, Klein UR, Lindner D, Ebert J, Nigg EA, Conti E, Cell. 2007 Oct 19;131(2):271-85. PMID:17956729 Page seeded by OCA on Sun May 4 14:51:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qfa"
Personal tools