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2qfi
From Proteopedia
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[[Image:2qfi.gif|left|200px]] | [[Image:2qfi.gif|left|200px]] | ||
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'''Structure of the zinc transporter YiiP''' | '''Structure of the zinc transporter YiiP''' | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Lu, M.]] | [[Category: Lu, M.]] | ||
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| - | [[Category: | + | [[Category: Zinc transporter]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:52:30 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 11:52, 4 May 2008
Structure of the zinc transporter YiiP
Overview
YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange across the inner membrane of Escherichia coli. Mammalian homologs of YiiP play critical roles in zinc homeostasis and cell signaling. Here, we report the x-ray structure of YiiP in complex with zinc at 3.8 angstrom resolution. YiiP is a homodimer held together in a parallel orientation through four Zn2+ ions at the interface of the cytoplasmic domains, whereas the two transmembrane domains swing out to yield a Y-shaped structure. In each protomer, the cytoplasmic domain adopts a metallochaperone-like protein fold; the transmembrane domain features a bundle of six transmembrane helices and a tetrahedral Zn2+ binding site located in a cavity that is open to both the membrane outer leaflet and the periplasm.
About this Structure
2QFI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of the zinc transporter YiiP., Lu M, Fu D, Science. 2007 Sep 21;317(5845):1746-8. Epub 2007 Aug 23. PMID:17717154 Page seeded by OCA on Sun May 4 14:52:30 2008
